Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.37 |
| ▸ | ESR1 | P03372 | 4/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1794969 | 0.69 | NPC1 (0.38) | KDM4EHSD17B10NPC1RAB9AKMT2A | |
| SCHEMBL4253508 | 0.69 | NPC1 (0.35) | KDM4ENPC1RAB9AALDH1A1GAA | |
| SCHEMBL1551968 | 0.69 | CDC7 (0.52) | GSK3B | |
| SCHEMBL28354471 | 0.68 | ESR1 (0.42) | KDM4EHSD17B10ESR1ESR2RAB9A | |
| SCHEMBL648577 | 0.67 | ESR1 (0.47) | KDM4EHSD17B10ESR1ESR2ALDH1A1 | |
| SCHEMBL1513802 | 0.65 | ATM (0.41) | KDM4EHSD17B10ESR1ESR2NPC1 | |
| SCHEMBL13170400 | 0.64 | RAB9A (0.74) | KDM4EHSD17B10NOTUMNPC1RAB9A | |
| SCHEMBL398659 | 0.64 | ATR (0.36) | KDM4EHSD17B10NPC1RAB9AALDH1A1 | |
| SCHEMBL2321269 | 0.64 | HTR1D (0.46) | KDM4EHSD17B10ESR1ESR2ALDH1A1 | |
| SCHEMBL16848496 | 0.63 | RAB9A (0.50) | KDM4EHSD17B10NOTUMNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313380-B1 | OXADIAZOLE DERIVATIVES FOR TREATING DIABETES | MERCK PATENT GMBH (DE) | 2013-12-11 | — | — | EP | claimed |
| US-8377975-B2 | Oxadiazole derivatives for the treatment of diabetes | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-02-19 | — | — | US | claimed |
| US-20110139654-A1 | OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES | MERCK PATENT GESELLSCHAFT (DE) | 2011-06-16 | — | — | US | claimed |
| EP-2313380-B1 | OXADIAZOLE DERIVATIVES FOR TREATING DIABETES | MERCK PATENT GMBH (DE) | 2013-12-11 | — | — | EP | disclosed |
| US-8377975-B2 | Oxadiazole derivatives for the treatment of diabetes | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-02-19 | — | — | US | disclosed |
| US-20110139654-A1 | OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES | MERCK PATENT GESELLSCHAFT (DE) | 2011-06-16 | — | — | US | disclosed |
| EP-2313380-A1 | OXADIAZOLE DERIVATIVES FOR TREATING DIABETES | Merck Patent GmbH (DE) | 2011-04-27 | — | — | EP | disclosed |
| WO-2010020305-A1 | OXADIAZOLE DERIVATIVES FOR TREATING DIABETES | MERCK PATENT GMBH (DE) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110139654-A1 | OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES | PFKL, RXFP3, OXA1L | KDM4E 1710/4885HSD17B10 1125/4885NOTUM 3429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.