Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3B | O95264 | 3/20 | 0.50 |
| ▸ | HTR3A | P46098 | 3/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1735647 | 0.81 | PRKCI (0.45) | HRH4HTTKDM4EALDH1A1 | |
| SCHEMBL24377348 | 0.72 | RPS6KB1 (0.35) | HRH4 | |
| SCHEMBL29622069 | 0.72 | LRRK2 (0.34) | HRH4ALDH1A1 | |
| SCHEMBL24377352 | 0.72 | LRRK2 (0.34) | HRH4ALDH1A1 | |
| SCHEMBL29622154 | 0.72 | RPS6KB1 (0.35) | HRH4 | |
| SCHEMBL24377347 | 0.71 | SMN1; SMN2 (0.49) | HTTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL15228263 | 0.71 | HTR3A (0.54) | HTR3BHTR3AHTR3EHTR3DHTR3C | |
| SCHEMBL10112808 | 0.71 | HRH4 (0.53) | HTR3BHTR3AHTR3EHTR3DHTR3C | |
| SCHEMBL30610994 | 0.70 | KDM4E (0.48) | KDM4EALDH1A1 | |
| SCHEMBL26629835 | 0.70 | KDM4E (0.48) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2909212-A1 | SUBSTITUTED-1,4-DIHYDROPYRAZOLO[4,3-b]INDOLES | Takeda Pharmaceutical Company Limited (JP) | 2015-08-26 | — | — | EP | disclosed |
| WO-2014039831-A1 | SUBSTITUTED-1,4-DIHYDROPYRAZOLO[4,3-b]INDOLES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-03-13 | — | — | WO | disclosed |