Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 6/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | TOP1 | P11387 | 6/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15519278 | 0.87 | HCRTR1 (0.41) | HCRTR1HCRTR2ATML3MBTL1CHRM1 | |
| SCHEMBL2393836 | 0.86 | CHRM1 (0.49) | HCRTR1HCRTR2CHRM1TOP1 | |
| SCHEMBL2394880 | 0.82 | ATM (0.44) | HCRTR1HCRTR2ATML3MBTL1CHRM1 | |
| SCHEMBL15520440 | 0.81 | HCRTR1 (0.43) | HCRTR1HCRTR2TP53MAPT | |
| SCHEMBL15520408 | 0.80 | CHRM1 (0.42) | CHRM1 | |
| SCHEMBL15520369 | 0.74 | CHRM1 (0.38) | HCRTR1HCRTR2ATML3MBTL1CHRM1 | |
| SCHEMBL15579846 | 0.73 | CHRM1 (0.52) | CHRM1TOP1 | |
| SCHEMBL15520587 | 0.72 | CHRM1 (0.38) | HCRTR1HCRTR2ATML3MBTL1CHRM1 | |
| SCHEMBL2397468 | 0.72 | CHRM1 (0.53) | CHRM1TOP1 | |
| SCHEMBL8010332 | 0.71 | CHRM1 (0.49) | CHRM1TOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252299-B1 | FUSED PYRIDONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2014-03-19 | — | — | EP | claimed |