Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.35 |
| ▸ | TOP1 | P11387 | 4/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.32 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15520369 | 0.91 | CHRM1 (0.38) | CHRM1HCRTR1HCRTR2TOP1CYP2D6 | |
| SCHEMBL2392743 | 0.85 | CHRM1 (0.49) | CHRM1TOP1LMNA | |
| SCHEMBL15520408 | 0.80 | CHRM1 (0.42) | CHRM1LMNATSHR | |
| SCHEMBL2395094 | 0.76 | CHRM1 (0.49) | CHRM1TOP1LMNA | |
| SCHEMBL15519384 | 0.75 | MEN1 (0.38) | HCRTR1HCRTR2TOP1CYP2D6CYP3A4 | |
| SCHEMBL15519278 | 0.75 | HCRTR1 (0.41) | CHRM1HCRTR1HCRTR2TOP1CYP2D6 | |
| SCHEMBL15520697 | 0.72 | HCRTR1 (0.43) | CHRM1HCRTR1HCRTR2TOP1ATM | |
| SCHEMBL8010272 | 0.71 | CHRM1 (0.51) | CHRM1TOP1LMNA | |
| SCHEMBL2490511 | 0.69 | LMNA (0.59) | CHRM1LMNA | |
| SCHEMBL2486079 | 0.68 | CHRM1 (0.70) | CHRM1TOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252299-B1 | FUSED PYRIDONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2014-03-19 | — | — | EP | claimed |