Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 8/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | ICMT | O60725 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 6/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.37 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15519278 | 0.90 | HCRTR1 (0.41) | HCRTR1HCRTR2 | |
| SCHEMBL2395575 | 0.88 | HCRTR1 (0.43) | HCRTR1HCRTR2GRM2ICMTITGA4 | |
| SCHEMBL15520697 | 0.81 | HCRTR1 (0.43) | HCRTR1HCRTR2TP53MAPT | |
| SCHEMBL8007510 | 0.76 | CHRM1 (0.43) | — | |
| SCHEMBL2397468 | 0.75 | CHRM1 (0.53) | — | |
| SCHEMBL2394956 | 0.73 | ATM (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL15520408 | 0.73 | CHRM1 (0.42) | — | |
| SCHEMBL12310584 | 0.72 | HCRTR1 (0.38) | HCRTR1HCRTR2 | |
| SCHEMBL8325773 | 0.72 | AGTR1 (0.40) | — | |
| SCHEMBL2393836 | 0.68 | CHRM1 (0.49) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252299-B1 | FUSED PYRIDONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2014-03-19 | — | — | EP | claimed |