Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.44 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1552347 | 1.00 | NPC1 (0.49) | NPC1RAB9AALDH1A1TSHRNPSR1 | |
| SCHEMBL1552035 | 0.83 | EPHA2 (0.46) | ALOX5EPHA2ERBB2EPHB4MAPT | |
| SCHEMBL1552036 | 0.83 | EPHA2 (0.46) | ALOX5EPHA2ERBB2EPHB4MAPT | |
| SCHEMBL1552531 | 0.81 | GPR119 (0.46) | EPHA2ERBB2EPHB4POLBALOX5AP | |
| SCHEMBL1552527 | 0.81 | GPR119 (0.46) | EPHA2ERBB2EPHB4POLBALOX5AP | |
| SCHEMBL1553213 | 0.81 | PPARG (0.43) | EPHA2ERBB2EPHB4TP53MAPT | |
| SCHEMBL1553210 | 0.81 | PPARG (0.43) | EPHA2ERBB2EPHB4TP53MAPT | |
| SCHEMBL1553330 | 0.80 | SMPD1 (0.42) | NPC1RAB9ANPSR1EPHA2ERBB2 | |
| SCHEMBL1553384 | 0.80 | SMPD1 (0.42) | NPC1RAB9ANPSR1EPHA2ERBB2 | |
| SCHEMBL31076359 | 0.79 | EPHA2 (0.51) | EPHA2ERBB2EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844026-B1 | MORPHOLINES AS 5HT2C AGONISTS | HOFFMANN LA ROCHE (CH) | 2011-04-27 | — | — | EP | disclosed |
| CN-101107235-B | Morpholines as 5HT2C agonists | HOFFMANN LA ROCHE | 2011-03-16 | — | — | CN | disclosed |
| US-7323466-B2 | Morpholine derivatives as 5HT2C receptor agonists for the treatment of obesity | HOFFMAN-LA ROCHE INC. (US) | 2008-01-29 | — | — | US | disclosed |
| CN-101107235-A | Morpholines as 5HT2C agonists | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | CN | disclosed |
| US-20060178510-A1 | New morpholine derivatives as 5HT2C receptor agonists for the treatment of obesity | HOFFMANN-LA ROCHE INC. | 2006-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178510-A1 | New morpholine derivatives as 5HT2C receptor agonists for the treatment of obesity | HTR2C, HTR1A, HTR1B | NPC1 1094/4885RAB9A 2441/4885ALDH1A1 541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.