Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.70 |
| ▸ | HPGD | P15428 | 5/20 | 0.70 |
| ▸ | THRB | P10828 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 7/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.66 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.66 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.66 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.66 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15525565 | 0.84 | KMT2A (0.75) | KMT2AALDH1A1NPSR1HPGDKAT8 | |
| SCHEMBL12285554 | 0.80 | KAT8 (0.81) | KMT2AALDH1A1NPSR1HPGDTDP1 | |
| SCHEMBL19983386 | 0.80 | KMT2A (0.75) | KMT2AALDH1A1NPSR1HPGDKAT8 | |
| SCHEMBL14596765 | 0.80 | KMT2A (1.00) | KMT2AALDH1A1NPSR1HPGDTDP1 | |
| SCHEMBL18153581 | 0.80 | KMT2A (0.74) | KMT2AALDH1A1NPSR1HPGDKAT8 | |
| SCHEMBL12285827 | 0.79 | ALDH1A1 (0.71) | KMT2AALDH1A1NPSR1HPGDTHRB | |
| SCHEMBL16686084 | 0.79 | KMT2A (0.64) | KMT2AALDH1A1NPSR1HPGDKAT8 | |
| SCHEMBL16686161 | 0.78 | KMT2A (0.63) | KMT2AALDH1A1NPSR1HPGDKAT8 | |
| SCHEMBL16685844 | 0.77 | KMT2A (0.62) | KMT2AALDH1A1NPSR1HPGDKAT8 | |
| SCHEMBL15525610 | 0.77 | KMT2A (0.64) | KMT2AALDH1A1NPSR1HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240043443-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | UNIV CASE WESTERN RESERVE (US) | 2024-02-08 | — | — | US | disclosed |
| US-20210032265-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-02-04 | — | — | US | disclosed |
| US-20210032265-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-02-04 | — | — | US | disclosed |
| US-20200140453-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-05-07 | — | — | US | disclosed |
| US-20200140453-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-05-07 | — | — | US | disclosed |
| US-10301320-B2 | Compositions and methods of modulating 15-PGDH activity | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2019-05-28 | — | — | US | disclosed |
| US-10301320-B2 | Compositions and methods of modulating 15-PGDH activity | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2019-05-28 | — | — | US | disclosed |
| EP-3295940-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | Case Western Reserve University (US) | 2018-03-21 | — | — | EP | disclosed |
| EP-3295940-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | Case Western Reserve University (US) | 2018-03-21 | — | — | EP | disclosed |
| US-9790233-B2 | Compositions and methods of modulating 15-PGDH activity | CASE WESTERN RESERVE UNIVERSITY (US) | 2017-10-17 | — | — | US | disclosed |
| EP-2838533-B1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | UNIV CASE WESTERN RESERVE (US) | 2017-10-04 | — | — | EP | disclosed |
| US-20170165241-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2017-06-15 | — | — | US | disclosed |
| US-20170165241-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2017-06-15 | — | — | US | disclosed |
| US-20170165241-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2017-06-15 | — | — | US | disclosed |
| US-20150072998-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2015-03-12 | — | — | US | disclosed |
| US-20150072998-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2015-03-12 | — | — | US | disclosed |
| US-20150072998-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2015-03-12 | — | — | US | disclosed |
| EP-2838533-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | Case Western Reserve University (US) | 2015-02-25 | — | — | EP | disclosed |
| WO-2013158649-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | CASE WESTERN RESERVE UNIVERSITY (US) | 2013-10-24 | — | — | WO | disclosed |
| WO-2013158649-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | CASE WESTERN RESERVE UNIVERSITY (US) | 2013-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170165241-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | PTGS1, HPGD, PTGIS | KMT2A 4177/4885ALDH1A1 415/4885NPSR1 3458/4885 |
| US-20200140453-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | PTGS1, HPGD, PTGIS | KMT2A 4177/4885ALDH1A1 415/4885NPSR1 3458/4885 |
| US-20240043443-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | PTGS1, HPGD, PTGIS | KMT2A 4177/4885ALDH1A1 415/4885NPSR1 3458/4885 |
| US-20150072998-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | PTGS1, HPGD, PTGIS | KMT2A 4177/4885ALDH1A1 415/4885NPSR1 3458/4885 |
| US-20210032265-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | PTGS1, HPGD, PTGIS | KMT2A 4177/4885ALDH1A1 415/4885NPSR1 3458/4885 |
| US-10301320-B2 | Compositions and methods of modulating 15-PGDH activity | PTGS1, HPGD, PTGIS | KMT2A 4177/4885ALDH1A1 415/4885NPSR1 3458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.