Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | OTC | P00480 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | NPY4R | P50391 | 4/20 | 0.33 |
| ▸ | NPY1R | P25929 | 3/20 | 0.33 |
| ▸ | NPY2R | P49146 | 2/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.33 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.33 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.32 |
| ▸ | ARG1 | P05089 | 1/20 | 0.32 |
| ▸ | CPB1 | P15086 | 1/20 | 0.32 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL29263954 | 0.99 | GSR (0.42) | GSRMMP2OTCITGB3ITGA2B | |
| Arginine SCHEMBL14764665 | 0.99 | GSR (0.42) | GSRMMP2OTCITGB3ITGA2B | |
| Arginine SCHEMBL28491547 | 0.99 | GSR (0.42) | GSRMMP2OTCITGB3ITGA2B | |
| Arginine SCHEMBL1063567 | 0.99 | GSR (0.42) | GSRMMP2OTCITGB3ITGA2B | |
| Arginine SCHEMBL693611 | 0.99 | GSR (0.42) | GSRMMP2OTCITGB3ITGA2B | |
| Arginine SCHEMBL2337389 | 0.95 | GSR (0.39) | GSRMMP2OTCITGB3ITGA2B | |
| Arginine SCHEMBL20918548 | 0.95 | GSR (0.39) | GSRMMP2OTCITGB3ITGA2B | |
| Arginine SCHEMBL4744077 | 0.94 | GSR (0.36) | GSRMMP2OTCITGB3ITGA2B | |
| Arginine SCHEMBL25294109 | 0.94 | GSR (0.38) | GSRMMP2OTCITGB3ITGA2B | |
| Arginine SCHEMBL8314691 | 0.94 | GSR (0.38) | GSRMMP2OTCITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013158273-A1 | METHODS TO MODULATE C-TERMINAL LYSINE VARIANT DISTRIBUTION | ABBVIE INC. (US) | 2013-10-24 | — | — | WO | disclosed |