Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NPY4R | P50391 | 7/20 | 0.35 |
| ▸ | NPY1R | P25929 | 5/20 | 0.35 |
| ▸ | NPY2R | P49146 | 4/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.34 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.34 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.34 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL20918548 | 1.00 | GSR (0.39) | GSRTHRBNPY4RNPY1RNPY2R | |
| Arginine SCHEMBL28491547 | 0.96 | GSR (0.42) | GSRTHRBNPY4RNPY1RNPY2R | |
| Arginine SCHEMBL29263954 | 0.96 | GSR (0.42) | GSRTHRBNPY4RNPY1RNPY2R | |
| Arginine SCHEMBL1063567 | 0.96 | GSR (0.42) | GSRTHRBNPY4RNPY1RNPY2R | |
| Arginine SCHEMBL693611 | 0.96 | GSR (0.42) | GSRTHRBNPY4RNPY1RNPY2R | |
| Arginine SCHEMBL14764665 | 0.96 | GSR (0.42) | GSRTHRBNPY4RNPY1RNPY2R | |
| Arginine SCHEMBL15525634 | 0.95 | GSR (0.41) | GSRTHRBNPY4RNPY1RNPY2R | |
| Arginine SCHEMBL29052768 | 0.94 | NPY4R (0.39) | GSRTHRBNPY4RNPY1RNPY2R | |
| Arginine SCHEMBL27456489 | 0.93 | NPY4R (0.39) | GSRTHRBNPY4RNPY1RNPY2R | |
| Arginine SCHEMBL25294109 | 0.91 | GSR (0.38) | GSRTHRBNPY4RNPY1RNPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170267736-A1 | IGF-I POLY (ETHYLENE GLYCOL) CONJUGATES | HOFFMANN-LA ROCHE INC. | 2017-09-21 | — | — | US | disclosed |
| US-9587006-B2 | IGF-I poly (ethylene glycol) conjugates | HOFFMANN-LA ROCHE INC. (US) | 2017-03-07 | — | — | US | disclosed |
| US-20120309679-A1 | IGF-I POLY (ETHYLENE GLYCOL) CONJUGATES | HOFFMANN-LA ROCHE INC. | 2012-12-06 | — | — | US | disclosed |
| WO-2011098400-A1 | IGF-I POLY (ETHYLENE GLYCOL) CONJUGATES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-18 | — | — | WO | disclosed |