Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 8/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.34 |
| ▸ | TUBB | P07437 | 3/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.34 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1552595 | 1.00 | PTGS1 (0.43) | PTGS1ALDH1A1CYP3A4RECQLMMP9 | |
| SCHEMBL17184026 | 0.93 | PTGS1 (0.51) | PTGS1ALDH1A1MMP9DRD2TUBB1 | |
| SCHEMBL2552196 | 0.93 | PTGS1 (0.51) | PTGS1ALDH1A1MMP9DRD2TUBB1 | |
| SCHEMBL31098830 | 0.93 | PTGS1 (0.48) | PTGS1ALDH1A1MMP9DRD2TUBB1 | |
| SCHEMBL1071168 | 0.83 | DRD2 (0.34) | ALDH1A1DRD2TUBB1KMT2ATUBB4A | |
| SCHEMBL23777899 | 0.80 | TUBB1 (0.43) | PTGS1ALDH1A1DRD2TUBB1KMT2A | |
| SCHEMBL15757538 | 0.80 | TUBB1 (0.43) | PTGS1ALDH1A1DRD2TUBB1KMT2A | |
| SCHEMBL17184004 | 0.80 | TUBB1 (0.43) | PTGS1ALDH1A1DRD2TUBB1KMT2A | |
| SCHEMBL7366745 | 0.80 | PREP (0.40) | PTGS1ALDH1A1CYP3A4RECQLKMT2A | |
| SCHEMBL7366750 | 0.80 | PREP (0.40) | PTGS1ALDH1A1CYP3A4RECQLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467967-B1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HOSPITAL FOR SICK CHILDREN (CA) | 2011-04-27 | — | — | EP | disclosed |
| US-7598419-B2 | Compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2009-10-06 | — | — | US | disclosed |
| US-7563820-B2 | Compounds for modulating cell proliferation | THE HOSPITAL FOR SICK CHILDREN (CA) | 2009-07-21 | — | — | US | disclosed |
| US-20070243612-A1 | Novel Compounds for Modulating Cell Proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2007-10-18 | — | — | US | disclosed |
| US-20070197660-A1 | Compounds for modulating cell proliferation | THE HOSPITAL FOR SICK CHILDREN (CA) | 2007-08-23 | — | — | US | disclosed |
| EP-1727822-A4 | NOVEL COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RES DEV LP (CA) | 2007-05-09 | — | — | EP | disclosed |
| EP-1752446-A2 | Compounds for modulating cell proliferation | HSC Research and Development Limited Partnership (CA) | 2007-02-14 | — | — | EP | disclosed |
| WO-2007006143-A1 | COMPOSITIONS AND METHODS FOR DETECTING TRANSFORMED CELLS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2007-01-18 | — | — | WO | disclosed |
| EP-1272457-B9 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RES DEV LP (CA) | 2006-12-20 | — | — | EP | disclosed |
| EP-1727822-A1 | NOVEL COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC Research and Development Limited Partnership (CA) | 2006-12-06 | — | — | EP | disclosed |
| EP-1453500-A1 | STYRYL ACRYLONITRILE COMPOUNDS AND THEIR USE TO PROMOTE MYELOPOIESIS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2004-09-08 | — | — | EP | disclosed |
| WO-2004032911-A2 | STYRYLACRYLONITRILE COMPOUNDS FOR INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR | THE HOSPITAL FOR SICK CHILDREN (CA) | 2004-04-22 | — | — | WO | disclosed |
| US-20040072803-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED (CA) | 2004-04-15 | — | — | US | disclosed |
| WO-2003062190-A1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2003-07-31 | — | — | WO | disclosed |
| US-20030109502-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2003-06-12 | — | — | US | disclosed |
| WO-2003030895-A1 | STYRYL ACRYLONITRILE COMPOUNDS AND THEIR USE TO PROMOTE MYELOPOIESIS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2003-04-17 | — | — | WO | disclosed |
| EP-1272457-A2 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC Research and Development Limited Partnership (CA) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001079158-A2 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2001-10-25 | — | — | WO | disclosed |
| US-5008471-A | Process for the preparation of rooperol | ROOPEROL (N.A.) (NL) | 1991-04-16 | — | — | US | disclosed |
| US-4956502-A | Process for the preparation of rooperol derivative | ROOPEROL (N.A.) NV (AN) | 1990-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070243612-A1 | Novel Compounds for Modulating Cell Proliferation | MKI67, CCNA1, PCNA | PTGS1 518/4885ALDH1A1 546/4885CYP3A4 4659/4885 |
| US-20030109502-A1 | Novel compounds for modulating cell proliferation | MKI67, CCNA1, CCNI | PTGS1 161/4885ALDH1A1 178/4885CYP3A4 4427/4885 |
| US-20070197660-A1 | Compounds for modulating cell proliferation | CCND3, CCNO, WNT3 | PTGS1 1737/4885ALDH1A1 2246/4885CYP3A4 3292/4885 |
| US-20040072803-A1 | Novel compounds for modulating cell proliferation | MKI67, CCNA1, MCL1 | PTGS1 158/4885ALDH1A1 179/4885CYP3A4 4285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.