Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 9/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PTGFR | P43088 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | F13A1 | P00488 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15543495 | 0.84 | NPSR1 (0.50) | CYP3A4KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL30001281 | 0.84 | NPSR1 (0.50) | CYP3A4KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL166146 | 0.76 | ACACB (0.54) | MTNR1AMTNR1BKDM4EALDH1A1LMNA | |
| SCHEMBL13605765 | 0.76 | ACACB (0.49) | MTNR1AMTNR1BKDM4EALDH1A1LMNA | |
| SCHEMBL48652 | 0.76 | HRH3 (0.61) | ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL12815784 | 0.75 | EGFR (0.46) | CYP3A4KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL19783133 | 0.75 | ALDH1A1 (0.41) | CYP3A4KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL12815455 | 0.75 | KDM4E (0.41) | MTNR1AMTNR1BCYP3A4KDM4EALDH1A1 | |
| SCHEMBL1871113 | 0.75 | KDM4E (0.47) | CYP3A4KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL19049449 | 0.74 | KDM4E (0.49) | MTNR1AMTNR1BCYP3A4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788336-A1 | BENZOTHIAZOL- 6 -YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING AN HIV INFECTION | Gilead Sciences, Inc. (US) | 2014-10-15 | — | — | EP | disclosed |
| WO-2013159064-A1 | BENZOTHIAZOL- 6 -YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING AN HIV INFECTION | GILEAD SCIENCES, INC. (US) | 2013-10-24 | — | — | WO | disclosed |