Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | VHL | P40337 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15543495 | 1.00 | NPSR1 (0.50) | NPSR1SETDB1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3475219 | 0.85 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL15526231 | 0.84 | MTNR1A (0.50) | SMN1; SMN2KDM4EALDH1A1CYP3A4MAPT | |
| SCHEMBL30451523 | 0.83 | NPSR1 (0.50) | NPSR1SETDB1ALDH1A1MAPTNPC1 | |
| SCHEMBL5729579 | 0.83 | NPSR1 (0.50) | NPSR1SETDB1ALDH1A1MAPTNPC1 | |
| SCHEMBL30204848 | 0.83 | ERCC1 (0.44) | SMN1; SMN2KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4726263 | 0.81 | KDM4E (0.40) | SMN1; SMN2KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL30982223 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL17801961 | 0.81 | NPSR1 (0.51) | NPSR1SETDB1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL23446458 | 0.80 | NPSR1 (0.50) | NPSR1SMN1; SMN2KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4347032-A1 | SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2024-04-10 | — | — | EP | disclosed |
| CN-117813302-A | Substituted tetrahydrofuran-2-carboxamides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2024-04-02 | — | — | CN | disclosed |
| WO-2022256702-A1 | SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-12-08 | — | — | WO | disclosed |