Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 2/20 | 0.31 |
| ▸ | SHMT1 | P34896 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15526431 | 1.00 | SLC22A12 (0.32) | SLC22A12RAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL15332821 | 0.81 | CYP3A4 (0.42) | RAB9AKDM4ENPC1SMN1; SMN2POLB | |
| SCHEMBL19894349 | 0.81 | KMO (0.34) | SLC22A12RAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL15333479 | 0.78 | CYP3A4 (0.34) | RAB9AGAA | |
| SCHEMBL15333481 | 0.78 | CYP3A4 (0.34) | RAB9AGAA | |
| SCHEMBL15526293 | 0.78 | SMN1; SMN2 (0.33) | SLC22A12RAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL15342426 | 0.77 | CYP3A4 (0.34) | RAB9AKDM4ENPC1SMN1; SMN2POLB | |
| SCHEMBL15331869 | 0.77 | ABL1 (0.39) | — | |
| SCHEMBL17530332 | 0.74 | — | — | |
| SCHEMBL17530325 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788336-A1 | BENZOTHIAZOL- 6 -YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING AN HIV INFECTION | Gilead Sciences, Inc. (US) | 2014-10-15 | — | — | EP | disclosed |
| WO-2013159064-A1 | BENZOTHIAZOL- 6 -YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING AN HIV INFECTION | GILEAD SCIENCES, INC. (US) | 2013-10-24 | — | — | WO | disclosed |