Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.42 |
| ▸ | RHEB | Q15382 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15604819 | 0.87 | TNKS (0.48) | TNKSMAPK14KDM4EALDH1A1WNT3A | |
| SCHEMBL15527577 | 0.80 | TNKS (0.53) | TNKSKDM4EALDH1A1WNT3ATNKS2 | |
| SCHEMBL15527859 | 0.79 | AHR (0.43) | TNKSWNT3ATNKS2PARP1SPR | |
| SCHEMBL23361516 | 0.78 | POLB (0.43) | TNKSMAPK14KDM4EALDH1A1WNT3A | |
| SCHEMBL16707618 | 0.78 | TNKS (0.51) | TNKSTNKS2PARP1SPR | |
| SCHEMBL16611551 | 0.78 | ALKBH5 (0.44) | TNKSTNKS2SMN1; SMN2PARP1ERCC1 | |
| SCHEMBL23361611 | 0.76 | TNKS (0.38) | TNKSMAPK14KDM4EALDH1A1WNT3A | |
| SCHEMBL15527455 | 0.76 | TNKS (0.63) | TNKSMAPK14KDM4EALDH1A1WNT3A | |
| SCHEMBL15287270 | 0.76 | TNKS (0.63) | TNKSMAPK14KDM4EALDH1A1TNKS2 | |
| SCHEMBL16520564 | 0.75 | TNKS (0.64) | TNKSKDM4EALDH1A1TNKS2RHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2844659-B1 | PYRROLOTRIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-05-25 | — | — | EP | disclosed |
| EP-2844659-B1 | PYRROLOTRIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-05-25 | — | — | EP | disclosed |
| US-9174995-B2 | Pyrrolotriazinone derivatives | MERCK PATENT GMBH (DE) | 2015-11-03 | — | — | US | disclosed |
| US-9174995-B2 | Pyrrolotriazinone derivatives | MERCK PATENT GMBH (DE) | 2015-11-03 | — | — | US | disclosed |
| US-9174995-B2 | Pyrrolotriazinone derivatives | MERCK PATENT GMBH (DE) | 2015-11-03 | — | — | US | disclosed |
| US-20150133453-A1 | PYRROLOTRIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-05-14 | — | — | US | disclosed |
| US-20150133453-A1 | PYRROLOTRIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-05-14 | — | — | US | disclosed |
| US-20150133453-A1 | PYRROLOTRIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-05-14 | — | — | US | disclosed |
| EP-2844659-A1 | PYRROLOTRIAZINONE DERIVATIVES | Merck Patent GmbH (DE) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013164061-A1 | PYRROLOTRIAZINONE DERIVATIVES | dedeMERCK PATENT GMBH (DE) | 2013-11-07 | — | — | WO | disclosed |
| WO-2013164061-A1 | PYRROLOTRIAZINONE DERIVATIVES | dedeMERCK PATENT GMBH (DE) | 2013-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133453-A1 | PYRROLOTRIAZINONE DERIVATIVES | TNKS, TBKBP1, TNKS1BP1 | TNKS 1/4885MAPK14 1319/4885MAPK13 2443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.