Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.65 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 11/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714541 | 0.79 | DAO (1.00) | DAOAURKAPARP1RIPK1 | |
| SCHEMBL671495 | 0.79 | DAO (0.65) | DAOAURKAPARP1RIPK1CCNB2 | |
| SCHEMBL29756947 | 0.79 | DAO (0.65) | DAOAURKAPARP1RIPK1CCNB2 | |
| SCHEMBL435130 | 0.79 | DAO (0.65) | DAOAURKAPARP1RIPK1CCNB2 | |
| SCHEMBL1574005 | 0.79 | DAO (0.65) | DAOAURKAPARP1RIPK1CCNB2 | |
| SCHEMBL668758 | 0.79 | DAO (0.65) | DAOAURKAPARP1RIPK1CCNB2 | |
| SCHEMBL21226786 | 0.79 | DAO (0.65) | DAOAURKAPARP1RIPK1CCNB2 | |
| SCHEMBL833073 | 0.78 | DAO (0.59) | DAOAURKAPARP1RIPK1CCNB2 | |
| SCHEMBL2595303 | 0.77 | DAO (0.53) | DAORIPK1CCNB2CDK1CCNB1 | |
| SCHEMBL6421464 | 0.76 | DAO (0.61) | DAOAURKAPARP1RIPK1CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250163078-A1 | IMIDAZOPYRIDAZINE DERIVATIVE, AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | Shanghai Simr Biotechnology Co., Ltd. (CN) | 2025-05-22 | — | — | US | disclosed |
| EP-4484433-A1 | IMIDAZOPYRIDAZINE DERIVATIVE, AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | Shanghai Simr Biotechnology Co., Ltd. (CN) | 2025-01-01 | — | — | EP | disclosed |
| US-11939314-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2024-03-26 | — | — | US | disclosed |
| CN-116693555-A | Imidazopyridazine derivative, preparation method, pharmaceutical composition and application thereof | 上海赛默罗生物科技有限公司 | 2023-09-05 | — | — | CN | disclosed |
| WO-2023160475-A1 | IMIDAZOPYRIDAZINE DERIVATIVE, AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | 上海赛默罗生物科技有限公司 | 2023-08-31 | — | — | WO | disclosed |
| US-20230028687-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-01-26 | — | — | US | disclosed |
| US-20230028687-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-01-26 | — | — | US | disclosed |
| US-11186562-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2021-11-30 | — | — | US | disclosed |
| US-11186562-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2021-11-30 | — | — | US | disclosed |
| US-11174241-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2021-11-16 | — | — | US | disclosed |
| US-20200190055-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-06-18 | — | — | US | disclosed |
| US-10669251-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2020-06-02 | — | — | US | disclosed |
| US-10669251-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2020-06-02 | — | — | US | disclosed |
| US-20190023685-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-01-24 | — | — | US | disclosed |
| US-20190023685-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-01-24 | — | — | US | disclosed |
| EP-3402792-A1 | QUINOLIN-2-ONE DERIVATIVES | Merck Patent GmbH (DE) | 2018-11-21 | — | — | EP | disclosed |
| WO-2017121444-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-07-20 | — | — | WO | disclosed |
| WO-2017121444-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-07-20 | — | — | WO | disclosed |
| US-20150094327-A1 | COMPOSITIONS AND METHODS FOR INHIBITING RESOLVASES | NATIONAL INSTITUTES OF HEALTH-DIRECTOR DEITR | 2015-04-02 | — | — | US | disclosed |
| WO-2013165898-A2 | COMPOSITIONS AND METHODS FOR INHIBITING RESOLVASES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11174241-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | DAO 3826/4885AURKA 125/4885PARP1 746/4885 |
| US-20190023685-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | DAO 3826/4885AURKA 125/4885PARP1 746/4885 |
| US-20250163078-A1 | IMIDAZOPYRIDAZINE DERIVATIVE, AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | CYP4A11, CYP4F11, SLC6A11 | DAO 2642/4885AURKA 1238/4885PARP1 4577/4885 |
| US-11939314-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | DAO 3826/4885AURKA 125/4885PARP1 746/4885 |
| US-20230028687-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | DAO 3826/4885AURKA 125/4885PARP1 746/4885 |
| US-20200190055-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | DAO 3826/4885AURKA 125/4885PARP1 746/4885 |
| US-10669251-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | DAO 3826/4885AURKA 125/4885PARP1 746/4885 |
| US-20150094327-A1 | COMPOSITIONS AND METHODS FOR INHIBITING RESOLVASES | FEN1, RCE1, APEX1 | DAO 2884/4885AURKA 2927/4885PARP1 97/4885 |
| US-11186562-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | DAO 3826/4885AURKA 125/4885PARP1 746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.