Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.65 |
| ▸ | RIPK1 | Q13546 | 10/20 | 0.53 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 2/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29691618 | 0.80 | DAO (0.54) | DAORIPK1AURKAPARP1CASP6 | |
| SCHEMBL671495 | 0.79 | DAO (0.65) | DAORIPK1AURKAPARP1CCNB2 | |
| SCHEMBL15528142 | 0.79 | DAO (0.65) | DAORIPK1AURKAPARP1CCNB2 | |
| SCHEMBL21226786 | 0.79 | DAO (0.65) | DAORIPK1AURKAPARP1CCNB2 | |
| SCHEMBL29756947 | 0.79 | DAO (0.65) | DAORIPK1AURKAPARP1CCNB2 | |
| SCHEMBL668758 | 0.79 | DAO (0.65) | DAORIPK1AURKAPARP1CCNB2 | |
| SCHEMBL3714541 | 0.79 | DAO (1.00) | DAORIPK1AURKAPARP1 | |
| SCHEMBL435130 | 0.79 | DAO (0.65) | DAORIPK1AURKAPARP1CCNB2 | |
| SCHEMBL7639694 | 0.77 | RIPK1 (0.59) | DAORIPK1CCNB2CDK1CCNB1 | |
| SCHEMBL1210670 | 0.77 | DAO (0.62) | DAORIPK1AURKAPARP1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3357922-B1 | 2-((5-(1-(3-(METHYLSULFONYL)PROPYL)PIPERIDIN-4-YL)PYRIDIN-2-YL)AMINO)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE DERIVATIVES AND RELATED COMPOUNDS AS CDK4 INHIBITORS FOR TREATING TUMORS | GUANGZHOU BEBETTER MEDICINE TECH CO LTD (CN) | 2020-08-26 | — | — | EP | disclosed |
| US-9714247-B2 | Multiple kinase pathway inhibitors | TOLERO PHARMACEUTICALS, INC. (US) | 2017-07-25 | — | — | US | disclosed |
| US-20170107215-A1 | MULTIPLE KINASE PATHWAY INHIBITORS | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2017-04-20 | — | — | US | disclosed |
| US-9493454-B2 | Multiple kinase pathway inhibitors | TOLERO PHARMACEUTICALS, INC. (US) | 2016-11-15 | — | — | US | disclosed |
| US-20150266870-A1 | MULTIPLE KINASE PATHWAY INHIBITORS | MANNKIND CORPORATION | 2015-09-24 | — | — | US | disclosed |
| EP-2900668-A1 | MULTIPLE KINASE PATHWAY INHIBITORS | MannKind Corporation (US) | 2015-08-05 | — | — | EP | disclosed |
| CN-104812756-A | Multiple kinase pathway inhibitors | MANNKIND CORP | 2015-07-29 | — | — | CN | disclosed |
| US-8586602-B2 | Derivatives of 7 alkynyl-1,8 naphthyridones, preparation method thereof and use of same in therapeutics | SANOFI (FR) | 2013-11-19 | — | — | US | disclosed |
| US-8470847-B2 | Derivatives of 7-alkynyl-1,8-naphthyridones, preparation method thereof and use of same in therapeutics | SANOFI (FR) | 2013-06-25 | — | — | US | disclosed |
| US-20120238598-A1 | DERIVATIVES OF 7 ALKYNYL-1,8 NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2012-09-20 | — | — | US | disclosed |
| US-8263614-B2 | Derivatives of 7-alkynyl-1,8-naphthyridones, preparation method thereof and use of same in therapeutics | SANOFI-AVENTIS (FR) | 2012-09-11 | — | — | US | disclosed |
| EP-2158201-B1 | DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2011-04-13 | — | — | EP | disclosed |
| US-20100144757-A1 | DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2010-06-10 | — | — | US | disclosed |
| US-20100144782-A1 | DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2010-06-10 | — | — | US | disclosed |
| EP-2158194-A2 | DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | Sanofi-Aventis (FR) | 2010-03-03 | — | — | EP | disclosed |
| EP-2158201-A2 | DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | Sanofi-Aventis (FR) | 2010-03-03 | — | — | EP | disclosed |
| WO-2009007536-A2 | DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2009-01-15 | — | — | WO | disclosed |
| WO-2009007535-A2 | DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2009-01-15 | — | — | WO | disclosed |
| JP-2002338570-A | METHOD FOR PRODUCING 3-AMINO-1,8-NAPHTHYRIDIN-2(1H)-ONE | SUMITOMO PHARMACEUT CO LTD | 2002-11-27 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266870-A1 | MULTIPLE KINASE PATHWAY INHIBITORS | MAP3K6, MAP3K2, MAP3K1 | DAO 3859/4885RIPK1 157/4885AURKA 356/4885 |
| US-20170107215-A1 | MULTIPLE KINASE PATHWAY INHIBITORS | MAP3K6, MAP3K2, MAP3K1 | DAO 3859/4885RIPK1 157/4885AURKA 356/4885 |
| US-20100144757-A1 | DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | ALK, ABL1, SMPD1 | DAO 4239/4885RIPK1 4736/4885AURKA 548/4885 |
| US-20100144782-A1 | DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | ALK, ABL1, NTPCR | DAO 4433/4885RIPK1 4749/4885AURKA 553/4885 |
| US-20120238598-A1 | DERIVATIVES OF 7 ALKYNYL-1,8 NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | FLT4, ALK, KDR | DAO 4303/4885RIPK1 3718/4885AURKA 935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.