Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.51 |
| ▸ | PNMT | P11086 | 6/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | DRD3 | P35462 | 4/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.32 |
| ▸ | CHRNG | P07510 | 1/20 | 0.32 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | CHRND | Q07001 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27582463 | 0.98 | TRPA1 (0.50) | TRPA1PNMTDRD2DRD3KDM1A | |
| SCHEMBL28331918 | 0.81 | TRPA1 (0.49) | TRPA1PNMTDRD2DRD3KDM1A | |
| SCHEMBL3296947 | 0.74 | DRD2 (0.42) | TRPA1PNMTDRD2DRD3KDM1A | |
| SCHEMBL26710938 | 0.73 | TRPA1 (0.48) | TRPA1PNMTDRD2DRD3KDM1A | |
| SCHEMBL148119 | 0.71 | CA1 (0.44) | TRPA1PNMTDRD2DRD3KDM1A | |
| SCHEMBL29740368 | 0.71 | CA1 (0.44) | TRPA1PNMTDRD2DRD3KDM1A | |
| SCHEMBL29740370 | 0.71 | CA1 (0.44) | TRPA1PNMTDRD2DRD3KDM1A | |
| SCHEMBL16406926 | 0.70 | MEN1 (0.46) | — | |
| SCHEMBL32680680 | 0.70 | CYP11B1 (0.43) | TRPA1PNMTDRD2DRD3KDM1A | |
| SCHEMBL27984426 | 0.70 | CYP11B1 (0.43) | TRPA1PNMTDRD2DRD3KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855456-A1 | COMPLEMENT PATHWAY MODULATORS AND USES THEREOF | Novartis AG (CH) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013164802-A1 | COMPLEMENT PATHWAY MODULATORS AND USES THEREOF | NOVARTIS AG (CH) | 2013-11-07 | — | — | WO | disclosed |