Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15528628 | 1.00 | BACE1 (0.38) | BACE1ROCK2FFAR1KCNH2MAPT | |
| SCHEMBL4238804 | 0.85 | ROCK2 (0.46) | BACE1ROCK2KCNH2MAPTPKM | |
| SCHEMBL4238780 | 0.85 | ROCK2 (0.46) | BACE1ROCK2KCNH2MAPTPKM | |
| SCHEMBL1817806 | 0.80 | ROCK2 (0.49) | BACE1ROCK2FFAR1KCNH2MAPT | |
| SCHEMBL1817691 | 0.80 | ROCK2 (0.49) | BACE1ROCK2MAPTF2RL1HDAC4 | |
| SCHEMBL1817810 | 0.80 | ROCK2 (0.49) | BACE1ROCK2FFAR1KCNH2MAPT | |
| SCHEMBL29350901 | 0.80 | ROCK2 (0.49) | BACE1ROCK2FFAR1KCNH2MAPT | |
| SCHEMBL1817686 | 0.80 | ROCK2 (0.49) | BACE1ROCK2MAPTF2RL1HDAC4 | |
| SCHEMBL1817812 | 0.80 | ROCK2 (0.49) | BACE1ROCK2FFAR1KCNH2MAPT | |
| SCHEMBL29352411 | 0.80 | ROCK2 (0.49) | BACE1ROCK2MAPTF2RL1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2844246-A1 | SUBSTRATES AND INHIBITORS OF PROLYL OLIGOPEPTIDASE AND FIBROBLAST ACTIVATION PROTEIN AND METHODS OF USE | The Board of Regents of the University of Oklahoma (US) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013166438-A1 | SUBSTRATES AND INHIBITORS OF PROLYL OLIGOPEPTIDASE AND FIBROBLAST ACTIVATION PROTEIN AND METHODS OF USE | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2013-11-07 | — | — | WO | disclosed |