Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.46 |
| ▸ | BACE1 | P56817 | 3/20 | 0.43 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | GRK2 | P25098 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | F2RL1 | P55085 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4238780 | 1.00 | ROCK2 (0.46) | ROCK2BACE1KDM1AHDAC4HRH3 | |
| SCHEMBL29352411 | 0.94 | ROCK2 (0.49) | ROCK2BACE1KDM1AHDAC4HRH3 | |
| SCHEMBL1817689 | 0.94 | ROCK2 (0.49) | ROCK2BACE1KDM1AHDAC4HRH3 | |
| SCHEMBL1817686 | 0.94 | ROCK2 (0.49) | ROCK2BACE1KDM1AHDAC4HRH3 | |
| SCHEMBL1817691 | 0.94 | ROCK2 (0.49) | ROCK2BACE1KDM1AHDAC4HRH3 | |
| SCHEMBL1815244 | 0.89 | ROCK2 (0.45) | ROCK2BACE1KDM1AHRH3CYP2C9 | |
| SCHEMBL1815252 | 0.89 | ROCK2 (0.45) | ROCK2BACE1KDM1AHRH3CYP2C9 | |
| SCHEMBL1815248 | 0.89 | ROCK2 (0.45) | ROCK2BACE1KDM1AHRH3CYP2C9 | |
| SCHEMBL4238784 | 0.87 | ROCK2 (0.45) | ROCK2BACE1KDM1AHDAC4HRH3 | |
| SCHEMBL15528626 | 0.85 | BACE1 (0.38) | ROCK2BACE1HDAC4F2RL1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038653-A2 | SUBSTRATES AND INHIBITORS OF ANTIPLASMIN CLEAVING ENZYME AND METHODS OF USE | McKee, Patrick A. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007146104-A2 | SUBSTRATES AND INHIBITORS OF ANTIPLASMIN CLEAVING ENZYME AND METHODS OF USE | MCKEE PATRICK A (US) | 2007-12-21 | — | — | WO | disclosed |