Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Isosorbide Dinitrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 0.78 |
| ▸ | BCHE | P06276 | 6/20 | 0.64 |
| ▸ | GSR | P00390 | 8/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isosorbide Dinitrate SCHEMBL19528695 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTBCHEGSRCA2 | |
| Isosorbide Dinitrate SCHEMBL9439417 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTBCHEGSRCA2 | |
| Isosorbide Dinitrate SCHEMBL29532755 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTBCHEGSRCA2 | |
| Isosorbide Dinitrate SCHEMBL8253 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTBCHEGSRCA2 | |
| Isosorbide Dinitrate SCHEMBL309369 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTBCHEGSRCA2 | |
| Isosorbide Dinitrate SCHEMBL3008938 | 0.98 | ALDH1A1 (0.95) | ALDH1A1MAPTBCHEGSRCA2 | |
| Isosorbide Dinitrate SCHEMBL714959 | 0.98 | ALDH1A1 (0.95) | ALDH1A1MAPTBCHEGSRCA2 | |
| Isosorbide Dinitrate SCHEMBL27976716 | 0.96 | ALDH1A1 (0.91) | ALDH1A1MAPTBCHEGSRCA2 | |
| Isosorbide Dinitrate SCHEMBL28209664 | 0.96 | ALDH1A1 (0.91) | ALDH1A1MAPTBCHEGSRCA2 | |
| Isosorbide Dinitrate SCHEMBL3864281 | 0.94 | ALDH1A1 (0.88) | ALDH1A1MAPTBCHEGSRCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200383634-A1 | MEDICAL SYSTEM FOR SEAMLESS THERAPY ADJUSTMENT | MEDTRONIC, INC. | 2020-12-10 | — | — | US | disclosed |
| EP-1456670-B8 | METHODS RELATING TO TREATMENT OF ATHEROSCLEROSIS | CAMBRIDGE THERANOSTICS LTD (GB) | 2011-04-27 | — | — | EP | disclosed |
| CN-101896161-A | Solid formulations of crystalline compounds | PURDUE RESEARCH FOUNDATION | 2010-11-24 | — | — | CN | disclosed |
| US-20100222311-A1 | SOLID FORMULATIONS OF CRYSTALLINE COMPOUNDS | PURDUE RESEARCH FOUNDATION (US) | 2010-09-02 | — | — | US | disclosed |
| EP-1456670-B1 | METHODS RELATING TO TREATMENT OF ATHEROSCLEROSIS | CAMBRIDGE THERANOSTICS LTD (GB) | 2009-07-15 | — | — | EP | disclosed |
| EP-1454140-B1 | DIAGNOSIS AND TREATMENT OF ATHEROSCLEROSIS | CAMBRIDGE THERANOSTICS LTD (GB) | 2009-07-08 | — | — | EP | disclosed |
| US-7504226-B2 | Methods relating to treatment of atherosclerosis | CAMBRIDGE THERANOSTICS LTD. (GB) | 2009-03-17 | — | — | US | disclosed |
| US-7419657-B2 | Reducing antibody-mediated lipid peroxidation activity in vascular systems; idiotypic antibodies; chlamydia pneumoniae vaccines | CAMBRIDGE THERANOSTICS LTD. (GB) | 2008-09-02 | — | — | US | disclosed |
| US-7148028-B2 | Methods and means relating to atherosclerosis | CAMBRIDGE THERANOSTICS LTD. (GB) | 2006-12-12 | — | — | US | disclosed |
| EP-1456670-A2 | METHODS RELATING TO TREATMENT OF ATHEROSCLEROSIS | Cambridge Theranostics Ltd. (GB) | 2004-09-15 | — | — | EP | disclosed |
| EP-1454140-A2 | DIAGNOSIS AND TREATMENT OF ATHEROSCLEROSIS | Cambridge Theranostics Ltd. (GB) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003019198-A2 | METHODS RELATING TO TREATMENT OF ATHEROSCLEROSIS | CAMBRIDGE THERANOSTICS LTD (GB) | 2003-03-06 | — | — | WO | disclosed |
| WO-2003019196-A2 | DIAGNOSIS AND TREATMENT OF ATHEROSCLEROSIS | CAMBRIDGE THERANOSTICS LTD (GB) | 2003-03-06 | — | — | WO | disclosed |
| US-5700516-A | WATERPROOFING PAPER | S. C. JOHNSON COMMERICAL MARKETS, INC. (US) | 1997-12-23 | — | — | US | disclosed |