Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | METAP1 | P53582 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29957028 | 0.84 | EGFR (0.50) | RAB9ANPC1KMT2AMEN1LMNA | |
| SCHEMBL31528241 | 0.76 | KAT2B (0.50) | KMT2AMEN1KDM4EGAAHPGD | |
| SCHEMBL29641309 | 0.76 | UTS2R (0.45) | MAPTKMT2AKDM4ELMNAUTS2R | |
| SCHEMBL15636237 | 0.76 | MAPT (0.73) | MAPTRAB9ANPC1KMT2AMEN1 | |
| SCHEMBL23426225 | 0.76 | TRIM24 (0.47) | MAPTRAB9ANPC1KMT2AMEN1 | |
| SCHEMBL18449482 | 0.74 | APP (0.53) | MAPTRAB9ANPC1KMT2AMEN1 | |
| SCHEMBL9392247 | 0.74 | NPC1 (1.00) | MAPTRAB9ANPC1KMT2AMEN1 | |
| SCHEMBL3716881 | 0.74 | MAPT (0.70) | MAPTRAB9ANPC1KMT2AMEN1 | |
| SCHEMBL3288225 | 0.73 | NPC1 (0.63) | MAPTRAB9ANPC1KMT2AMEN1 | |
| SCHEMBL1376342 | 0.72 | DHODH (0.56) | MAPTRAB9ANPC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2846803-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | Anvyl, LLC (US) | 2015-03-18 | — | — | EP | claimed |
| WO-2013169889-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ANVYL LLC (US) | 2013-11-14 | — | — | WO | claimed |
| EP-2846803-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | Anvyl, LLC (US) | 2015-03-18 | — | — | EP | disclosed |
| WO-2013169889-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ANVYL LLC (US) | 2013-11-14 | — | — | WO | disclosed |