Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | METAP1 | P53582 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31368779 | 0.83 | RAB9A (0.47) | MAPTNPC1RAB9AL3MBTL1HTT | |
| SCHEMBL2785512 | 0.82 | ALDH1A1 (0.50) | APPMAPTRAB9AHTTLMNA | |
| SCHEMBL3953540 | 0.79 | APP (0.53) | APPMAPTNPC1RAB9AL3MBTL1 | |
| SCHEMBL9609215 | 0.77 | HTT (0.59) | APPMAPTNPC1RAB9AHTT | |
| SCHEMBL4308925 | 0.77 | PIK3CD (0.52) | MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3111587 | 0.74 | RAB9A (0.74) | APPMAPTNPC1RAB9AHTT | |
| SCHEMBL15530810 | 0.74 | MAPT (0.58) | APPMAPTNPC1RAB9AL3MBTL1 | |
| SCHEMBL9609203 | 0.74 | GALR3 (0.58) | APPMAPTNPC1RAB9AHTT | |
| SCHEMBL31240809 | 0.73 | CCNC (0.58) | APPMAPTRAB9AHTTLMNA | |
| SCHEMBL9374978 | 0.73 | RAB9A (0.59) | APPMAPTNPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3331863-A1 | NOVEL COMPOUNDS AS ROR GAMMA MODULATORS | Glenmark Pharmaceuticals S.A. (CH) | 2018-06-13 | — | — | EP | disclosed |
| WO-2017021879-A1 | NOVEL COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2017-02-09 | — | — | WO | disclosed |