Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.51 |
| ▸ | BCL2 | P10415 | 1/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15533244 | 0.85 | HTR2A (0.62) | HTR2AKMT2APOLBHTR2C | |
| SCHEMBL7652993 | 0.82 | HTR2A (0.55) | HTR2AHTR2C | |
| SCHEMBL28683652 | 0.81 | BCL2 (0.52) | BCL2BCL2L1ALOX5HSP90AA1HSP90AB1 | |
| SCHEMBL27708168 | 0.79 | BCL2 (0.50) | BCL2BCL2L1ALOX5HSP90AA1HSP90AB1 | |
| SCHEMBL7637946 | 0.79 | HTR2A (0.49) | HTR2AKMT2APOLBL3MBTL1 | |
| SCHEMBL7630243 | 0.78 | HTR2A (0.48) | HTR2AKMT2APOLBHTR2CL3MBTL1 | |
| SCHEMBL7077110 | 0.77 | GAA (0.49) | KMT2AMEN1HPGD | |
| SCHEMBL876094 | 0.76 | BCL2 (0.59) | BCL2BCL2L1ALOX5HSP90AA1KMT2A | |
| SCHEMBL2514742 | 0.75 | BCL2 (0.82) | BCL2BCL2L1ALOX5HSP90AA1KMT2A | |
| SCHEMBL7636001 | 0.75 | POLB (0.53) | HTR2AKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855475-B1 | ALPHA-CARBOLINES FOR THE TREATMENT OF CANCER | UNIVERSITÀ DEGLI STUDI DI MILANO - BICOCCA (IT) | 2017-06-28 | — | — | EP | disclosed |
| CN-104540823-B | Alpha-carbolines for the treatment of cancer | 米兰-比科卡大学 | 2017-02-22 | — | — | CN | disclosed |
| US-9428500-B2 | Alpha-carbolines for the treatment of cancer | UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA (IT) | 2016-08-30 | — | — | US | disclosed |
| US-20150105554-A1 | ALPHA-CARBOLINES FOR THE TREATMENT OF CANCER | UNIVERSITE DE GENEVE (CH) | 2015-04-16 | — | — | US | disclosed |
| EP-2855475-A1 | ALPHA-CARBOLINES FOR THE TREATMENT OF CANCER | Università Degli Studi Di Milano - Bicocca (IT) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013167730-A1 | ALPHA-CARBOLINES FOR THE TREATMENT OF CANCER | UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA (IT) | 2013-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105554-A1 | ALPHA-CARBOLINES FOR THE TREATMENT OF CANCER | ALK, CSNK1A1, BRAF | HTR2A 3377/4885BCL2 764/4885BCL2L1 404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.