Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR1E | P28566 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1539290 | 0.86 | SLC5A2 (0.52) | HTR2AL3MBTL1HTR2C | |
| SCHEMBL17267483 | 0.86 | HTR2A (0.49) | HTR2A | |
| SCHEMBL7652993 | 0.85 | HTR2A (0.55) | HTR2AGPR55MAPTHTR2C | |
| SCHEMBL19019371 | 0.85 | HTR2A (0.50) | HTR2AGPR55MAPTPOLBKMT2A | |
| SCHEMBL6155160 | 0.85 | LMNA (0.44) | MAPTKMT2AL3MBTL1 | |
| SCHEMBL1539208 | 0.84 | SLC5A2 (0.50) | HTR2A | |
| SCHEMBL7637946 | 0.83 | HTR2A (0.49) | HTR2AGPR55MAPTPOLBKMT2A | |
| SCHEMBL15533244 | 0.82 | HTR2A (0.62) | HTR2APOLBKMT2AHTR2C | |
| SCHEMBL1539263 | 0.81 | SLC5A2 (0.54) | — | |
| SCHEMBL15532149 | 0.78 | HTR2A (0.51) | HTR2APOLBKMT2AL3MBTL1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224195-A1 | C-ARYL GLUCOSIDE SGLT2 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001027128-A1 | C-ARYL GLUCOSIDE SGLT2 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-04-19 | — | — | WO | disclosed |