Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1304390 | 0.90 | PDGFRB (0.51) | ALDH1A1KMT2APDGFRBPDGFRAMEN1 | |
| SCHEMBL346309 | 0.86 | PDGFRB (0.50) | ALDH1A1KMT2APDGFRBPDGFRAMEN1 | |
| SCHEMBL348341 | 0.85 | PDGFRB (0.67) | ALDH1A1KMT2APDGFRBPDGFRAMEN1 | |
| SCHEMBL348350 | 0.84 | CYP1A2 (0.47) | ALDH1A1KMT2APDGFRBPDGFRAMEN1 | |
| SCHEMBL15329252 | 0.82 | FYN (0.49) | ALDH1A1KMT2APDGFRBPDGFRAMEN1 | |
| SCHEMBL15328208 | 0.81 | MAPT (0.47) | ALDH1A1KMT2APDGFRBPDGFRAMEN1 | |
| SCHEMBL23068690 | 0.81 | CYP1A2 (0.54) | ALDH1A1KMT2APDGFRBPDGFRAMEN1 | |
| SCHEMBL15327931 | 0.81 | ALDH1A1 (0.44) | ALDH1A1KMT2APDGFRBPDGFRAMEN1 | |
| SCHEMBL347611 | 0.81 | ALDH1A1 (0.44) | ALDH1A1KMT2APDGFRBPDGFRAMEN1 | |
| SCHEMBL15328263 | 0.80 | PDGFRB (0.54) | ALDH1A1KMT2APDGFRBPDGFRAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013175281-A1 | USE OF SUBSTITUTED 2-PHENYL-3H-QUINAZOLIN-4-ONES AND ANALOGS FOR INHIBITING BROMODOMAIN AND EXTRA TERMINAL DOMAIN (BET) PROTEINS | RVX THERAPEUTICS INC. (CA) | 2013-11-28 | — | — | WO | disclosed |