Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | PKLR | P30613 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 8/20 | 0.45 |
| ▸ | CCR3 | P51677 | 8/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15586373 | 0.91 | PKM (0.50) | PKMPKLRLMNAGAASMN1; SMN2 | |
| SCHEMBL12600344 | 0.81 | PKM (0.48) | PKMPKLRLMNAGAASMN1; SMN2 | |
| SCHEMBL15532807 | 0.80 | CRBN (0.47) | TP53 | |
| SCHEMBL15586421 | 0.77 | CYP3A4 (0.49) | LMNACYP3A4CYP2D6CYP2C19MEN1 | |
| SCHEMBL15586408 | 0.77 | CYP3A4 (0.56) | LMNASMN1; SMN2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL1991670 | 0.77 | ALOX5 (0.51) | PKMLMNAGAASMN1; SMN2CYP3A4 | |
| SCHEMBL4579159 | 0.76 | GRIN2D (0.47) | PKMLMNASMN1; SMN2KCNH2 | |
| SCHEMBL15586418 | 0.76 | KCNH2 (0.47) | LMNASMN1; SMN2MEN1KMT2AKCNH2 | |
| SCHEMBL429773 | 0.75 | HRH3 (0.55) | MAPT | |
| SCHEMBL15746493 | 0.74 | SMN1; SMN2 (0.48) | PKMLMNAGAASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013170072-A2 | COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | NEUROP, INC. (US) | 2013-11-14 | — | — | WO | disclosed |
| WO-2013170072-A2 | COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | NEUROP, INC. (US) | 2013-11-14 | — | — | WO | disclosed |