Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 9/20 | 0.62 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | RBP4 | P02753 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13753537 | 0.84 | AKR1C3 (0.62) | AKR1C3HRH4HRH3POLBSMN1; SMN2 | |
| SCHEMBL15064997 | 0.84 | AKR1C3 (0.62) | AKR1C3HRH4HRH3POLBSMN1; SMN2 | |
| SCHEMBL24235367 | 0.83 | AKR1C3 (0.61) | AKR1C3HRH4HRH3POLBSMN1; SMN2 | |
| SCHEMBL13201971 | 0.82 | AKR1C3 (0.63) | AKR1C3HRH4HRH3POLBSMN1; SMN2 | |
| SCHEMBL30310614 | 0.82 | AKR1C3 (0.60) | AKR1C3HRH4HRH3POLBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6823552 | 0.80 | AKR1C3 (0.57) | AKR1C3HRH4HRH3POLBSMN1; SMN2 | |
| SCHEMBL30402971 | 0.79 | AKR1C3 (0.65) | AKR1C3HRH4HRH3POLBSMN1; SMN2 | |
| SCHEMBL11981489 | 0.77 | AKR1C3 (1.00) | AKR1C3HRH4HRH3POLBSMN1; SMN2 | |
| SCHEMBL2350768 | 0.76 | HRH4 (0.78) | AKR1C3HRH4HRH3POLBSMN1; SMN2 | |
| SCHEMBL29944207 | 0.75 | HRH4 (0.76) | AKR1C3HRH4HRH3POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013175281-A1 | USE OF SUBSTITUTED 2-PHENYL-3H-QUINAZOLIN-4-ONES AND ANALOGS FOR INHIBITING BROMODOMAIN AND EXTRA TERMINAL DOMAIN (BET) PROTEINS | RVX THERAPEUTICS INC. (CA) | 2013-11-28 | — | — | WO | disclosed |