Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.76 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.76 |
| ▸ | POLB | P06746 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.64 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | CA7 | P43166 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2345954 | 1.00 | HRH4 (0.76) | HRH4HRH3POLBSMN1; SMN2NPC1 | |
| SCHEMBL2350768 | 0.98 | HRH4 (0.78) | HRH4HRH3POLBSMN1; SMN2NPC1 | |
| SCHEMBL602187 | 0.88 | HRH4 (0.74) | HRH4HRH3POLBSMN1; SMN2DRD2 | |
| SCHEMBL22615143 | 0.87 | HRH4 (0.89) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| Benzoxazolinone SCHEMBL3094881 | 0.86 | POLB (0.60) | HRH4HRH3POLBSMN1; SMN2NPC1 | |
| SCHEMBL28469741 | 0.86 | HRH4 (0.74) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL29699763 | 0.86 | HRH4 (1.00) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL2679610 | 0.86 | HRH4 (1.00) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| Potassium Ion SCHEMBL22615122 | 0.85 | HRH4 (0.71) | HRH4HRH3POLBSMN1; SMN2NPC1 | |
| SCHEMBL22615176 | 0.85 | HRH4 (0.74) | HRH4HRH3POLBSMN1; SMN2AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230110003-A1 | PIPERIDINE DERIVATIVES AND COMPOSITIONS FOR THE INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | Valo Health, LLC | 2023-04-13 | — | — | US | disclosed |
| CN-115943307-A | MR1 ligands and pharmaceutical compositions for immunomodulation | 巴塞尔大学 | 2023-04-07 | — | — | CN | disclosed |
| US-11479564-B2 | Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT) | VALO HEALTH, INC. (US) | 2022-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230110003-A1 | PIPERIDINE DERIVATIVES AND COMPOSITIONS FOR THE INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | NAMPT, NAPRT, NNMT | HRH4 2277/4885HRH3 1783/4885POLB 907/4885 |
| US-11479564-B2 | Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT) | NAMPT, NAPRT, NNMT | HRH4 2277/4885HRH3 1783/4885POLB 907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.