Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.78 |
| ▸ | HPGD | P15428 | 5/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.78 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.52 |
| ▸ | TNF | P01375 | 3/20 | 0.52 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.52 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15256369 | 0.88 | MAPT (0.78) | MAPTALDH1A1HPGDKDM4EALOX15 | |
| SCHEMBL1718839 | 0.88 | MAPT (1.00) | MAPTALDH1A1HPGDKDM4EALOX15 | |
| SCHEMBL17189283 | 0.81 | ALDH1A1 (0.72) | MAPTALDH1A1HPGDKDM4EALOX15 | |
| SCHEMBL15921037 | 0.81 | MAPT (0.52) | MAPTALDH1A1HPGDKDM4EALOX15 | |
| SCHEMBL2949670 | 0.80 | ALDH1A1 (1.00) | MAPTALDH1A1HPGDKDM4EALOX15 | |
| SCHEMBL21247239 | 0.80 | ALDH1A1 (1.00) | MAPTALDH1A1HPGDKDM4EALOX15 | |
| SCHEMBL3914470 | 0.80 | MAPT (1.00) | MAPTALDH1A1HPGDKDM4EALOX15 | |
| SCHEMBL21260633 | 0.79 | TNF (0.62) | MAPTALDH1A1HPGDKDM4EALOX15 | |
| SCHEMBL14195744 | 0.77 | MAPT (0.65) | MAPTALDH1A1HPGDKDM4EALOX15 | |
| SCHEMBL3498811 | 0.76 | ALDH1A1 (0.59) | MAPTALDH1A1HPGDKDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2852595-B1 | SUBSTITUTED BENZOTHIENOPYRIMIDINES | Bayer Pharma AG (DE) | 2016-06-22 | — | — | EP | disclosed |
| US-20160159816-A1 | SUBSTITUTED THIENOPYRIMIDINES AND PHARMACEUTICAL USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-06-09 | — | — | US | disclosed |
| US-9296757-B2 | Substituted benzothienopyrimidines | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-03-29 | — | — | US | disclosed |
| EP-2951187-A1 | SUBSTITUTED THIENOPYRIMIDINES AND PHARMACEUTICAL USE THEREOF | Bayer Pharma Aktiengesellschaft (DE) | 2015-12-09 | — | — | EP | disclosed |
| US-20150152121-A1 | Substituted Benzothienopyrimidines | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-06-04 | — | — | US | disclosed |
| EP-2852595-A1 | SUBSTITUTED BENZOTHIENOPYRIMIDINES | Bayer Pharma Aktiengesellschaft (DE) | 2015-04-01 | — | — | EP | disclosed |
| WO-2014118229-A1 | SUBSTITUTED THIENOPYRIMIDINES AND PHARMACEUTICAL USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-08-07 | — | — | WO | disclosed |
| WO-2013174735-A1 | SUBSTITUTED BENZOTHIENOPYRIMIDINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2013-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152121-A1 | Substituted Benzothienopyrimidines | CCNA1, CCNT2, TYMP | MAPT 2395/4885ALDH1A1 545/4885HPGD 517/4885 |
| US-20160159816-A1 | SUBSTITUTED THIENOPYRIMIDINES AND PHARMACEUTICAL USE THEREOF | TYMP, DPYD, TYMS | MAPT 2076/4885ALDH1A1 507/4885HPGD 60/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.