Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.58 |
| ▸ | CDK2 | P24941 | 4/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.56 |
| ▸ | SYK | P43405 | 3/20 | 0.55 |
| ▸ | AURKA | O14965 | 3/20 | 0.55 |
| ▸ | CDK4 | P11802 | 2/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | BCR | P11274 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15534256 | 0.85 | CCNT1 (0.47) | GSK3BCDK2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL15534016 | 0.81 | SYK (0.53) | GSK3BCDK2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL15534241 | 0.81 | CLK1 (0.63) | GSK3BCDK2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL3247345 | 0.81 | CDK2 (0.56) | GSK3BCDK2AURKACDK4ABL1 | |
| SCHEMBL27116070 | 0.79 | PIK3CG (0.57) | GSK3BCDK2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL12298125 | 0.79 | CSNK2A1 (0.59) | GSK3BAPPLMNAMAPTMAPK1 | |
| SCHEMBL3257741 | 0.78 | PIK3CG (0.56) | GSK3BCDK2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL12274955 | 0.77 | ABL1 (0.56) | GSK3BCDK2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL27116137 | 0.76 | GSK3B (0.65) | GSK3BCDK2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL25337941 | 0.76 | AURKA (0.62) | GSK3BCDK2AURKACDK4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | claimed |
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | disclosed |