Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.53 |
| ▸ | CDK9 | P50750 | 4/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | FLT1 | P17948 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15534256 | 0.83 | CCNT1 (0.47) | SYKCDK9CCNT1MKNK2MKNK1 | |
| SCHEMBL15533818 | 0.82 | CYP2D6 (0.50) | SYKCDK9CCNT1MAP4K4FGFR1 | |
| SCHEMBL15533895 | 0.81 | GSK3B (0.58) | SYKCDK9FLT3MAP4K4FGFR1 | |
| SCHEMBL15533965 | 0.81 | SYK (0.51) | SYKFLT3CLK4DYRK1APIK3CA | |
| SCHEMBL27115517 | 0.78 | SYK (0.47) | SYKCDK5ABL1GSK3BCDK2 | |
| SCHEMBL30451078 | 0.73 | CYP1A1 (0.55) | — | |
| SCHEMBL27115516 | 0.72 | SYK (0.48) | SYKPLK1 | |
| SCHEMBL3524417 | 0.72 | IKBKB (0.71) | CDK9CCNT1MAPK8GSK3B | |
| SCHEMBL15534293 | 0.71 | SYK (0.49) | SYKFLT3CLK4DYRK1BCLK2 | |
| SCHEMBL17145021 | 0.69 | CYP1A1 (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | claimed |
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | disclosed |