Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 3/20 | 0.47 |
| ▸ | CDK9 | P50750 | 3/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 4/20 | 0.45 |
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | CLK2 | P49760 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | STK16 | O75716 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | CLK3 | P49761 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
| ▸ | NEK4 | P51957 | 1/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15533895 | 0.85 | GSK3B (0.58) | CDK9FLT3SRCZAP70SYK | |
| SCHEMBL15534016 | 0.83 | SYK (0.53) | CCNT1CDK9MKNK2MKNK1FLT3 | |
| SCHEMBL15533545 | 0.80 | DYRK1A (0.49) | FLT3SRCZAP70SYKCDK2 | |
| SCHEMBL27115514 | 0.76 | SYK (0.52) | SRCZAP70SYKCDK2CDK4 | |
| SCHEMBL30451078 | 0.74 | CYP1A1 (0.55) | CRHR1 | |
| SCHEMBL25337185 | 0.72 | PIK3CA (0.54) | SRCZAP70SYKCDK2CDK4 | |
| SCHEMBL30554567 | 0.72 | PIK3CA (0.54) | SRCZAP70SYKCDK2CDK4 | |
| SCHEMBL30554485 | 0.72 | KCNH2 (0.57) | SRCZAP70SYKCDK2CDK4 | |
| SCHEMBL25337625 | 0.72 | KCNH2 (0.57) | SRCZAP70SYKCDK2CDK4 | |
| SCHEMBL3524417 | 0.71 | IKBKB (0.71) | CCNT1CDK9GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | claimed |
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | disclosed |