Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.31 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CFTR | P13569 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15535829 | 0.93 | ALDH1A1 (0.39) | ALDH1A1DYRK1AMEN1KMT2AENPP1 | |
| SCHEMBL29391508 | 0.93 | ALDH1A1 (0.39) | ALDH1A1DYRK1AMEN1KMT2AENPP1 | |
| SCHEMBL29391980 | 0.88 | GAA (0.36) | ALDH1A1MEN1KMT2AENPP1KDM4E | |
| SCHEMBL15535973 | 0.88 | GAA (0.36) | ALDH1A1MEN1KMT2AENPP1KDM4E | |
| SCHEMBL16969048 | 0.85 | ALDH1A1 (0.43) | ALDH1A1DYRK1AMEN1KMT2AENPP1 | |
| SCHEMBL15534847 | 0.81 | HTR1A (0.36) | ALDH1A1MEN1KMT2AENPP1KDM4E | |
| SCHEMBL29391518 | 0.81 | HTR1A (0.36) | ALDH1A1MEN1KMT2AENPP1KDM4E | |
| SCHEMBL15557568 | 0.80 | NSD2 (0.34) | ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL16969049 | 0.80 | ALDH1A1 (0.42) | ALDH1A1DYRK1AMEN1KMT2AENPP1 | |
| SCHEMBL15535447 | 0.80 | ALDH1A1 (0.38) | ALDH1A1DYRK1AMEN1KMT2AENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855426-A1 | CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS | Orion Corporation (FI) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013175053-A1 | CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS | ORION CORPORATION (FI) | 2013-11-28 | — | — | WO | disclosed |