Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | EIF4A1 | P60842 | 2/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28022013 | 0.92 | FAAH (0.44) | FAAHCES1KCNH2KCNJ1CCNC | |
| SCHEMBL545799 | 0.77 | ABL1 (0.53) | TSHRCYP19A1CYP11B1CYP11B2LMNA | |
| SCHEMBL826630 | 0.76 | TSHR (0.50) | CES1TSHRALDH1A1LMNANPSR1 | |
| SCHEMBL1847096 | 0.74 | TSHR (0.64) | KCNH2KCNJ1TSHRCYP19A1ALDH1A1 | |
| SCHEMBL3133571 | 0.74 | APP (0.51) | CDK8TSHRALDH1A1LMNANPC1 | |
| SCHEMBL546042 | 0.71 | ABL1 (0.44) | FAAHCES1TSHRCYP19A1CYP11B1 | |
| SCHEMBL23365096 | 0.70 | NPC1 (0.42) | FAAHCES1TSHRALDH1A1LMNA | |
| SCHEMBL546381 | 0.70 | ABL1 (0.59) | CYP19A1CYP11B1CYP11B2LMNAMAPT | |
| SCHEMBL29978954 | 0.70 | NPC1 (0.42) | FAAHCES1TSHRALDH1A1LMNA | |
| SCHEMBL1816182 | 0.68 | TSHR (0.62) | TSHRALDH1A1LMNAMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2852572-A1 | CARBOLINE AND CARBAZOLE BASED IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION | Eli Lilly and Company (US) | 2015-04-01 | — | — | EP | disclosed |
| WO-2013176698-A1 | CARBOLINE AND CARBAZOLE BASED IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION | ELI LILLY AND COMPANY (US) | 2013-11-28 | — | — | WO | disclosed |