Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 8/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.30 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.30 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15730059 | 0.71 | FFAR3 (0.33) | FFAR3SLC22A12TSHR | |
| SCHEMBL6897915 | 0.69 | FFAR3 (0.35) | FFAR3SLC22A12 | |
| SCHEMBL17153412 | 0.68 | — | — | |
| SCHEMBL4193152 | 0.63 | CES2 (0.36) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL21202695 | 0.63 | CYP2C19 (0.35) | — | |
| SCHEMBL15729969 | 0.63 | CYP2C19 (0.35) | FFAR3SLC22A12TSHR | |
| SCHEMBL18793 | 0.61 | CYP2C19 (0.38) | FFAR3SLC22A12TSHRALDH1A1 | |
| SCHEMBL31040454 | 0.61 | MEN1 (0.37) | MEN1KMT2AAKR1B1TSHRALDH1A1 | |
| SCHEMBL1327047 | 0.61 | CYP2C19 (0.43) | MEN1KMT2AAKR1B1TSHRALDH1A1 | |
| SCHEMBL8712062 | 0.61 | CES2 (0.50) | FFAR3HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855469-A1 | 5-AMINO[1,4]THIAZINES AS BACE 1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013174781-A1 | 5-AMINO[1,4]THIAZINES AS BACE 1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-11-28 | — | — | WO | disclosed |