Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 3/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 8/20 | 0.33 |
| ▸ | BRS3 | P32247 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
| ▸ | SKP1 | P63208 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | KDM6A | O15550 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19371330 | 0.83 | EIF2AK4 (0.46) | KDM4DPDE10ACKS1BSKP1SKP2 | |
| SCHEMBL18430031 | 0.83 | EIF2AK4 (0.36) | BRS3 | |
| SCHEMBL15535236 | 0.83 | EIF2AK4 (0.36) | BRS3 | |
| SCHEMBL19371102 | 0.83 | EIF2AK4 (0.46) | KDM4DPDE10ACKS1BSKP1SKP2 | |
| SCHEMBL15883556 | 0.82 | PIM2 (0.35) | KDM4DBRS3MAP4K4 | |
| SCHEMBL16587791 | 0.81 | PIM2 (0.38) | KDM4DGPR119 | |
| SCHEMBL15547790 | 0.81 | EIF2AK4 (0.34) | NAMPTKDM4DBRS3PDE10A | |
| SCHEMBL15883550 | 0.80 | PIM2 (0.39) | KDM4DBRS3 | |
| SCHEMBL16587837 | 0.80 | GPR119 (0.34) | NAMPTKDM4DGPR119 | |
| SCHEMBL19371100 | 0.78 | BRS3 (0.35) | KDM4DBRS3GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2861585-A1 | NOVEL RING-SUBSTITUTED N-PYRIDINYL AMIDES AS KINASE INHIBITORS | Novartis AG (CH) | 2015-04-22 | — | — | EP | disclosed |
| WO-2013175388-A1 | NOVEL RING-SUBSTITUTED N-PYRIDINYL AMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2013-11-28 | — | — | WO | disclosed |