Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 6/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.35 |
| ▸ | SKP1 | P63208 | 1/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | KDM6A | O15550 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19371330 | 1.00 | EIF2AK4 (0.46) | EIF2AK4AURKAPDPK1AURKBPDE10A | |
| SCHEMBL15932915 | 0.84 | EIF2AK4 (0.48) | EIF2AK4AURKAPDPK1AURKBPDE10A | |
| SCHEMBL2836323 | 0.84 | EIF2AK4 (0.48) | EIF2AK4AURKAPDPK1AURKBPDE10A | |
| SCHEMBL11912156 | 0.84 | EIF2AK4 (0.48) | EIF2AK4AURKAPDPK1AURKBPDE10A | |
| SCHEMBL15932916 | 0.84 | EIF2AK4 (0.48) | EIF2AK4AURKAPDPK1AURKBPDE10A | |
| SCHEMBL11912148 | 0.84 | EIF2AK4 (0.48) | EIF2AK4AURKAPDPK1AURKBPDE10A | |
| SCHEMBL2836325 | 0.84 | EIF2AK4 (0.48) | EIF2AK4AURKAPDPK1AURKBPDE10A | |
| SCHEMBL19371088 | 0.83 | EIF2AK4 (0.47) | EIF2AK4AURKAPDPK1AURKBPIM1 | |
| SCHEMBL15535908 | 0.83 | NFKB1 (0.34) | PDE10AKDM4DCKS1BSKP1SKP2 | |
| SCHEMBL15535236 | 0.83 | EIF2AK4 (0.36) | EIF2AK4PIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2943485-B1 | BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE HOLDINGS CORP (US) | 2017-09-20 | — | — | EP | disclosed |