Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28066537 | 0.84 | SCN9A (0.32) | SCN9AFFAR3 | |
| SCHEMBL23547281 | 0.81 | NPSR1 (0.32) | SCN9ANPSR1MAPTMMP1 | |
| SCHEMBL1814154 | 0.80 | NPSR1 (0.32) | SCN9ANPSR1MAPTMMP1 | |
| SCHEMBL1814156 | 0.80 | NPSR1 (0.32) | SCN9ANPSR1MAPTMMP1 | |
| SCHEMBL1809492 | 0.80 | NPSR1 (0.32) | SCN9ANPSR1MAPTMMP1 | |
| SCHEMBL17002625 | 0.79 | NPSR1 (0.31) | NPSR1FFAR3MAPT | |
| Hydrochloric Acid SCHEMBL1812451 | 0.79 | NPSR1 (0.31) | NPSR1MAPTMMP1 | |
| Hydrochloric Acid SCHEMBL1812447 | 0.79 | NPSR1 (0.31) | NPSR1MAPTMMP1 | |
| Hydrochloric Acid SCHEMBL1812449 | 0.79 | NPSR1 (0.31) | NPSR1MAPTMMP1 | |
| SCHEMBL6845298 | 0.79 | FFAR3 (0.52) | SCN9ANPSR1FFAR3MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855428-A1 | N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN | Genentech, Inc. (US) | 2015-04-08 | — | — | EP | disclosed |
| US-8952169-B2 | N-substituted benzamides and methods of use thereof | XENON PHARMACEUTICALS INC. (CA) | 2015-02-10 | — | — | US | disclosed |
| WO-2013177224-A1 | N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN | GENENTECH, INC. (US) | 2013-11-28 | — | — | WO | disclosed |