Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.62 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1553114 | 0.88 | HRH3 (0.61) | HRH3CYP2D6KDM1A | |
| Hydrochloric Acid SCHEMBL3248065 | 0.85 | HRH3 (0.76) | HRH3CYP2D6 | |
| SCHEMBL3241070 | 0.78 | HRH3 (0.79) | HRH3CYP2D6 | |
| SCHEMBL3247232 | 0.77 | HRH3 (0.76) | HRH3CYP2D6 | |
| SCHEMBL3249806 | 0.77 | HRH3 (0.76) | HRH3CYP2D6 | |
| SCHEMBL3243602 | 0.77 | HRH3 (0.76) | HRH3CYP2D6 | |
| SCHEMBL1379627 | 0.77 | HRH3 (1.00) | HRH3CYP2D6 | |
| SCHEMBL1552607 | 0.77 | HRH3 (0.76) | HRH3CYP2D6 | |
| SCHEMBL1552905 | 0.77 | HRH3 (0.46) | HRH3CYP2D6 | |
| SCHEMBL3250550 | 0.76 | HRH3 (0.74) | HRH3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968967-B1 | 1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS | HOFFMANN LA ROCHE (CH) | 2011-04-27 | — | — | EP | disclosed |