Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 6/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1552728 | 0.84 | HRH3 (0.45) | HRH3CYP2D6CLK1DYRK1ADYRK1B | |
| SCHEMBL1553470 | 0.77 | ABCB11 (0.46) | HRH3CYP2D6HPGDCLK1DYRK1A | |
| SCHEMBL22004384 | 0.74 | KMT2A (0.51) | HRH3CYP2D6ALDH1A1HSD17B10HRH4 | |
| SCHEMBL22004143 | 0.73 | ACLY (0.53) | HRH3CYP2D6HPGDHSD17B10HRH4 | |
| SCHEMBL27787697 | 0.70 | HRH3 (0.51) | HRH3CYP2D6KMT2A | |
| SCHEMBL4494253 | 0.70 | HPGD (0.55) | HPGDCLK1DYRK1ADYRK1BALDH1A1 | |
| SCHEMBL3167147 | 0.69 | HRH3 (0.50) | HRH3CYP2D6 | |
| SCHEMBL3165664 | 0.68 | HRH3 (0.49) | HRH3CYP2D6 | |
| SCHEMBL27739848 | 0.68 | HRH3 (0.48) | HRH3CYP2D6HPGDKMT2A | |
| SCHEMBL3543062 | 0.68 | HRH3 (0.66) | HRH3CYP2D6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968967-B1 | 1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS | HOFFMANN LA ROCHE (CH) | 2011-04-27 | — | — | EP | disclosed |
| EP-1968967-A1 | 1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007062997-A1 | 1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |