Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.54 |
| ▸ | NPC1 | O15118 | 7/20 | 0.54 |
| ▸ | RAB9A | P51151 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 8/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2084371 | 0.90 | IMPDH2 (0.55) | MAPTNPC1RAB9ASMN1; SMN2JAK3 | |
| SCHEMBL2084374 | 0.90 | IMPDH2 (0.55) | MAPTNPC1RAB9ASMN1; SMN2JAK3 | |
| SCHEMBL16790671 | 0.86 | MEN1 (0.60) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL15537939 | 0.84 | BACE1 (0.48) | MAPTNPC1RAB9ASMN1; SMN2JAK3 | |
| SCHEMBL2086187 | 0.84 | MEN1 (0.62) | MAPTNPC1RAB9ASMN1; SMN2JAK3 | |
| SCHEMBL2086185 | 0.84 | MEN1 (0.62) | MAPTNPC1RAB9ASMN1; SMN2JAK3 | |
| SCHEMBL15538768 | 0.83 | MEN1 (0.58) | MAPTNPC1RAB9ASMN1; SMN2JAK3 | |
| SCHEMBL29678247 | 0.83 | PARP1 (0.58) | MAPTNPC1RAB9ASMN1; SMN2JAK3 | |
| SCHEMBL18929474 | 0.83 | MEN1 (0.55) | MAPTNPC1RAB9ASMN1; SMN2JAK3 | |
| SCHEMBL2085438 | 0.83 | PARP1 (0.58) | MAPTNPC1RAB9ASMN1; SMN2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10301598-B2 | Low-molecular-compound for improving production, maintenance and proliferation of pluripotent stem cells, composition comprising the same, and culture method | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2019-05-28 | — | — | US | disclosed |
| US-20170159023-A1 | NOVEL LOW-MOLECULAR-COMPOUND FOR IMPROVING PRODUCTION, MAINTENANCE AND PROLIFERATION OF PLURIPOTENT STEM CELLS, COMPOSITION COMPRISING THE SAME, AND CULTURE METHOD | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2017-06-08 | — | — | US | disclosed |
| EP-2774918-B1 | NOVEL LOW-MOLECULAR WEIGHT COMPOUND FOR PROMOTING PLURIPOTENT STEM CELL GENERATION, MAINTENANCE, AND PROLIFERATION, AND COMPOSITION AND CULTURING METHOD CONTAINING SAME | KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR) | 2017-03-22 | — | — | EP | disclosed |
| US-9587225-B2 | Low-molecular-compound for improving production, maintenance and proliferation of pluripotent stem cells, composition comprising the same, and culture method | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2017-03-07 | — | — | US | disclosed |
| US-20150159142-A1 | NOVEL LOW-MOLECULAR-COMPOUND FOR IMPROVING PRODUCTION, MAINTENANCE AND PROLIFERATION OF PLURIPOTENT STEM CELLS, COMPOSITION COMPRISING THE SAME, AND CULTURE METHOD | Korea Reasearch Institute of Bioscience and Biotechnology (KR) | 2015-06-11 | — | — | US | disclosed |
| EP-2774918-A1 | NOVEL LOW-MOLECULE COMPOUND FOR PROMOTING PLURIPOTENT STEM CELL GENERATION, MAINTENANCE, AND PROLIFERATION, AND COMPOSITION AND CULTURING METHOD CONTAINING SAME | Korea Research Institute of Bioscience and Biotechology (KR) | 2014-09-10 | — | — | EP | disclosed |
| WO-2013180350-A1 | NOVEL LOW-MOLECULE COMPOUND FOR PROMOTING PLURIPOTENT STEM CELL GENERATION, MAINTENANCE, AND PROLIFERATION, AND COMPOSITION AND CULTURING METHOD CONTAINING SAME | 한국생명공학연구원 (KR) | 2013-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150159142-A1 | NOVEL LOW-MOLECULAR-COMPOUND FOR IMPROVING PRODUCTION, MAINTENANCE AND PROLIFERATION OF PLURIPOTENT STEM CELLS, COMPOSITION COMPRISING THE SAME, AND CULTURE METHOD | MYC, MYCBP, HES1 | MAPT 3105/4885NPC1 4780/4885RAB9A 4062/4885 |
| US-10301598-B2 | Low-molecular-compound for improving production, maintenance and proliferation of pluripotent stem cells, composition comprising the same, and culture method | AANAT, MKI67, VIM | MAPT 2405/4885NPC1 4608/4885RAB9A 4645/4885 |
| US-20170159023-A1 | NOVEL LOW-MOLECULAR-COMPOUND FOR IMPROVING PRODUCTION, MAINTENANCE AND PROLIFERATION OF PLURIPOTENT STEM CELLS, COMPOSITION COMPRISING THE SAME, AND CULTURE METHOD | AANAT, MKI67, ACP1 | MAPT 3253/4885NPC1 4664/4885RAB9A 4684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.