SCHEMBL15536840

SCHEMBL15536840

COC(=O)c1cc(Cl)c(OCC23CC4CC(C2)CC(CO[Si](C)(C)C(C)(C)C)(C4)C3)cc1F

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 20/20 0.56
SCN5A Q14524 3/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16448664 0.87 SCN9A (0.61) SCN9ASCN5A
SCHEMBL15536029 0.87 SCN9A (0.61) SCN9ASCN5A
SCHEMBL15549240 0.84 SCN9A (0.74) SCN9A
SCHEMBL15536348 0.78 SCN9A (0.65) SCN9ASCN5A
SCHEMBL16448663 0.77 SCN9A (0.60) SCN9ASCN5A
SCHEMBL15560102 0.76 SCN9A (0.54) SCN9ASCN5A
SCHEMBL15536123 0.76 SCN9A (0.59) SCN9ASCN5A
SCHEMBL15536471 0.75 SCN9A (0.71) SCN9ASCN5A
SCHEMBL19429998 0.75 SCN9A (0.72) SCN9ASCN5A
SCHEMBL15543439 0.72 SCN9A (0.41) SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2855428-A1 N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN Genentech, Inc. (US) 2015-04-08 EP disclosed
WO-2013177224-A1 N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN GENENTECH, INC. (US) 2013-11-28 WO disclosed