SCHEMBL16448663

SCHEMBL16448663

CCC12CC3CC(C1)CC(COc1cc(F)c(C(=O)O)cc1Cl)(C3)C2

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 20/20 0.60
SCN5A Q14524 3/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15536123 0.90 SCN9A (0.59) SCN9ASCN5A
SCHEMBL16448664 0.90 SCN9A (0.61) SCN9ASCN5A
SCHEMBL15536898 0.88 SCN9A (0.69) SCN9ASCN5A
SCHEMBL15536029 0.81 SCN9A (0.61) SCN9ASCN5A
SCHEMBL16448665 0.81 SCN9A (0.82) SCN9A
SCHEMBL19429998 0.81 SCN9A (0.72) SCN9ASCN5A
SCHEMBL15536896 0.80 SCN9A (0.72) SCN9ASCN5A
SCHEMBL19429994 0.78 SCN9A (0.71) SCN9ASCN5A
SCHEMBL15537282 0.78 SCN9A (0.71) SCN9ASCN5A
SCHEMBL19411522 0.77 SCN9A (0.58) SCN9ASCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8952169-B2 N-substituted benzamides and methods of use thereof XENON PHARMACEUTICALS INC. (CA) 2015-02-10 US disclosed