Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.44 |
| ▸ | GLRA1 | P23415 | 2/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16785955 | 0.85 | GLRA1 (0.47) | GLRA1LIPECCR5MAPK1ALDH1A1 | |
| SCHEMBL15539512 | 0.84 | GLRA1 (0.56) | TBXA2RPTGER1GLRA1MAPK1ALDH1A1 | |
| SCHEMBL12889910 | 0.83 | GLRA1 (0.50) | GLRA1MRGPRX4LIPECCR5MAPK1 | |
| SCHEMBL15729686 | 0.83 | MRGPRX4 (0.52) | TBXA2RPTGER1MRGPRX4 | |
| SCHEMBL4455681 | 0.82 | NPC1 (0.50) | TBXA2RPTGER1MRGPRX4RAB9A | |
| SCHEMBL15538392 | 0.81 | AR (0.40) | LMNAL3MBTL1ACSS2 | |
| SCHEMBL15537162 | 0.79 | GLRA1 (0.48) | TBXA2RPTGER1GLRA1MAPK1ALDH1A1 | |
| SCHEMBL24781012 | 0.79 | HTR2C (0.53) | PTGER1MRGPRX4FFAR4 | |
| SCHEMBL15540035 | 0.78 | ADRA2A (0.43) | MAPK1ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL8800593 | 0.78 | GLRA1 (0.50) | GLRA1LIPECCR5MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422248-B2 | Phenyl- and pyridinyl-substituted 2,2,2-trifluoroethanols having anticonvulsant properties | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2016-08-23 | — | — | US | claimed |
| US-20150158821-A1 | SUBSTITUTED PHENOLS HAVING ANTICONVULSANT PROPERTIES | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2015-06-11 | — | — | US | claimed |
| WO-2013188716-A1 | SUBSTITUTED PHENOLS HAVING ANTICONVULSANT PROPERTIES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2013-12-19 | — | — | WO | claimed |
| US-9422248-B2 | Phenyl- and pyridinyl-substituted 2,2,2-trifluoroethanols having anticonvulsant properties | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2016-08-23 | — | — | US | disclosed |
| US-9422248-B2 | Phenyl- and pyridinyl-substituted 2,2,2-trifluoroethanols having anticonvulsant properties | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2016-08-23 | — | — | US | disclosed |
| US-20150158821-A1 | SUBSTITUTED PHENOLS HAVING ANTICONVULSANT PROPERTIES | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2015-06-11 | — | — | US | disclosed |
| US-20150158821-A1 | SUBSTITUTED PHENOLS HAVING ANTICONVULSANT PROPERTIES | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2015-06-11 | — | — | US | disclosed |
| WO-2013188716-A1 | SUBSTITUTED PHENOLS HAVING ANTICONVULSANT PROPERTIES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2013-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150158821-A1 | SUBSTITUTED PHENOLS HAVING ANTICONVULSANT PROPERTIES | PNMT, COMT, GABRE | TBXA2R 480/4885PTGER1 511/4885GLRA1 836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.