Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A2 | P43004 | 3/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.50 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.45 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.45 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.45 |
| ▸ | GSR | P00390 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 3/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ARG1 | P05089 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methionine Sulfoxide SCHEMBL15538307 | 1.00 | SLC1A2 (0.50) | SLC1A2SLC1A1SLC1A3DDAH1GRIK1 | |
| Methionine Sulfoxide SCHEMBL689512 | 0.89 | GSR (0.46) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Methionine Sulfoxide SCHEMBL689456 | 0.89 | GSR (0.46) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Methionine Sulfoxide SCHEMBL288041 | 0.89 | GSR (0.46) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Methionine Sulfoxide SCHEMBL38626 | 0.89 | GSR (0.46) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Methionine Sulfoxide SCHEMBL995666 | 0.89 | GSR (0.46) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Methionine Sulfoxide SCHEMBL4418369 | 0.89 | GSR (0.46) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Methionine Sulfoxide SCHEMBL14448373 | 0.89 | GSR (0.46) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Methionine Sulfoxide SCHEMBL38627 | 0.89 | GSR (0.46) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Methionine Sulfoxide SCHEMBL22076611 | 0.87 | GSR (0.45) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897632-A2 | COMPOUNDS MODULATING ASTROCYTIC RELEASE OF SUBSTANCES THROUGH CONNEXINS AND PANNEXINS AND TREATMENT OF PSYCHIATRIC DISORDERS | Universidad Andres Bello (CL) | 2015-07-29 | — | — | EP | claimed |
| WO-2013179264-A2 | USE OF COMPOUNDS THAT SELECTIVELY MODULATE ASTROCYTIC RELEASE OF SUBSTANCES THROUGH HEMICHANNELS OF CONNEXINS AND PANNEXINS, WITHOUT INFLUENCING GAP JUNCTIONS, FOR THE TREATMENT OF PSYCHIATRIC DISORDERS | UNIVERSIDAD ANDRES BELLO (CL) | 2013-12-05 | — | — | WO | claimed |
| EP-2897632-A2 | COMPOUNDS MODULATING ASTROCYTIC RELEASE OF SUBSTANCES THROUGH CONNEXINS AND PANNEXINS AND TREATMENT OF PSYCHIATRIC DISORDERS | Universidad Andres Bello (CL) | 2015-07-29 | — | — | EP | disclosed |
| WO-2013179264-A2 | USE OF COMPOUNDS THAT SELECTIVELY MODULATE ASTROCYTIC RELEASE OF SUBSTANCES THROUGH HEMICHANNELS OF CONNEXINS AND PANNEXINS, WITHOUT INFLUENCING GAP JUNCTIONS, FOR THE TREATMENT OF PSYCHIATRIC DISORDERS | UNIVERSIDAD ANDRES BELLO (CL) | 2013-12-05 | — | — | WO | disclosed |