Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | PHGDH | O43175 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15540890 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAHTTHPGDTSHR | |
| SCHEMBL15540895 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAHTTHPGDTSHR | |
| SCHEMBL8727982 | 0.77 | MGLL (0.59) | SMN1; SMN2LMNAHTTHPGDTSHR | |
| SCHEMBL16781072 | 0.72 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAHTTHPGDTSHR | |
| SCHEMBL16781071 | 0.72 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAHTTHPGDTSHR | |
| SCHEMBL16781273 | 0.70 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAHTTHPGDTSHR | |
| SCHEMBL16781272 | 0.70 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAHTTHPGDTSHR | |
| SCHEMBL946143 | 0.70 | HPGD (0.86) | SMN1; SMN2LMNAHPGDTSHRPHGDH | |
| SCHEMBL30449295 | 0.69 | HPGD (0.83) | SMN1; SMN2LMNAHPGDTSHRPHGDH | |
| Ammonia Solution, Strong SCHEMBL6028542 | 0.69 | HPGD (0.83) | SMN1; SMN2LMNAHPGDTSHRPHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230140433-A1 | INHIBITORS OF BTK AND MUTANTS THEREOF | NEWAVE PHARMACEUTICAL INC. | 2023-05-04 | — | — | US | disclosed |
| US-20200377478-A1 | INHIBITORS OF BTK AND MUTANTS THEREOF | NEWAVE PHARMACEUTICAL INC. | 2020-12-03 | — | — | US | disclosed |
| EP-2844642-A1 | COMPOUNDS FOR INHIBITING CELL PROLIFERATION IN EGFR-DRIVEN CANCERS | ARIAD PHARMACEUTICALS, INC. (US) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013169401-A1 | COMPOUNDS FOR INHIBITING CELL PROLIFERATION IN EGFR-DRIVEN CANCERS | ARIAD PHARMACEUTICALS, INC. (US) | 2013-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230140433-A1 | INHIBITORS OF BTK AND MUTANTS THEREOF | BTK, SYK, LYN | SMN1; SMN2 3898/4885LMNA 3480/4885HTT 4040/4885 |
| US-20200377478-A1 | INHIBITORS OF BTK AND MUTANTS THEREOF | BTK, SYK, LYN | SMN1; SMN2 3913/4885LMNA 3695/4885HTT 4018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.