Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.32 |
| ▸ | TPSD1 | Q9BZJ3 | 3/20 | 0.32 |
| ▸ | TPSG1 | Q9NRR2 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15543405 | 0.86 | MAPK13 (0.39) | MAPK13MAPK12MAPK11MAPK14NAAA | |
| SCHEMBL28614001 | 0.85 | MAPK13 (0.40) | MAPK13MAPK12MAPK11MAPK14NAAA | |
| SCHEMBL2544784 | 0.85 | GSR (0.47) | MAPK13MAPK12MAPK11MAPK14TPSAB1 | |
| SCHEMBL30912985 | 0.85 | GSR (0.43) | MAPK13MAPK12MAPK11MAPK14L3MBTL1 | |
| SCHEMBL3344777 | 0.85 | NAAA (0.39) | MAPK13MAPK12MAPK11MAPK14NAAA | |
| SCHEMBL30022635 | 0.83 | NAAA (0.51) | MAPK13MAPK12MAPK11MAPK14NAAA | |
| SCHEMBL7782965 | 0.83 | GSR (0.46) | MAPK13MAPK12MAPK11MAPK14NAAA | |
| SCHEMBL7782967 | 0.83 | GSR (0.46) | MAPK13MAPK12MAPK11MAPK14NAAA | |
| SCHEMBL4027366 | 0.82 | NAAA (0.39) | MAPK13MAPK12MAPK11MAPK14NAAA | |
| SCHEMBL4031737 | 0.82 | NAAA (0.39) | MAPK13MAPK12MAPK11MAPK14NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864291-B1 | N-[4-(QUINOLIN-4-YLOXY)CYCLOHEXYL(METHYL)](HETERO)ARYLCARBOXAMIDES AS ANDROGEN RECEPTOR ANTAGONISTS, PRODUCTION AND USE THEREOF AS MEDICINAL PRODUCTS | Bayer Pharma AG (DE) | 2016-10-05 | — | — | EP | disclosed |
| US-9428460-B2 | N-[4-(quinolin-4-yloxy)cyclohexyl(methyl)](hetero)arylcarboxamides as androgen receptor antagonists, production and use thereof as medicinal products | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-08-30 | — | — | US | disclosed |
| US-20150191431-A1 | N-[4-(Quinolin-4-yloxy)cyclohexyl(methyl)](hetero)arylcarboxamides as androgen receptor antagonists, production and use thereof as medicinal products | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-07-09 | — | — | US | disclosed |
| EP-2864291-A1 | N-[4-(QUINOLIN-4-YLOXY)CYCLOHEXYL(METHYL)](HETERO)ARYLCARBOXAMIDES AS ANDROGEN RECEPTOR ANTAGONISTS, PRODUCTION AND USE THEREOF AS MEDICINAL PRODUCTS | Bayer Pharma Aktiengesellschaft (DE) | 2015-04-29 | — | — | EP | disclosed |
| WO-2014001247-A1 | N-[4-(Quinolin-4-yloxy)cyclohexyl(methyl)](hetero)arylcarboxamides as androgen receptor antagonists, production and use thereof as medicinal products | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150191431-A1 | N-[4-(Quinolin-4-yloxy)cyclohexyl(methyl)](hetero)arylcarboxamides as androgen receptor antagonists, production and use thereof as medicinal products | AR, NR5A1, CYP19A1 | MAPK13 2441/4885MAPK12 1815/4885MAPK11 2457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.