Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.41 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 9/20 | 0.40 |
| ▸ | AKT1 | P31749 | 4/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30577876 | 0.82 | HCAR2 (0.40) | RPS6KB1AKT1TDP1 | |
| SCHEMBL29558330 | 0.80 | PARP1 (0.62) | PARP1PKN1PKN2RPS6KB1AKT1 | |
| SCHEMBL528715 | 0.80 | PARP1 (0.62) | PARP1PKN1PKN2RPS6KB1AKT1 | |
| Hydrochloric Acid SCHEMBL31382875 | 0.79 | PARP1 (0.60) | PARP1PKN1PKN2RPS6KB1AKT1 | |
| SCHEMBL29638622 | 0.79 | PARP1 (0.44) | PARP1RPS6KB1AKT1 | |
| SCHEMBL29638494 | 0.78 | PARP1 (0.51) | PARP1RPS6KB1AKT1SIRT3TDP1 | |
| SCHEMBL10175098 | 0.77 | PARP1 (0.67) | PARP1PKN1PKN2SIRT3TDP1 | |
| SCHEMBL3265420 | 0.75 | RPS6KB1 (0.43) | PKN1PKN2RPS6KB1AKT1 | |
| SCHEMBL29638640 | 0.74 | PARP1 (0.46) | PARP1RPS6KB1 | |
| SCHEMBL3663171 | 0.74 | SIRT3 (0.42) | RPS6KB1AKT1SIRT3TDP1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022089219-A1 | ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-05-05 | — | — | WO | disclosed |
| EP-2861595-A2 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS | Incyte Corporation (US) | 2015-04-22 | — | — | EP | disclosed |
| WO-2014007951-A2 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS | INCYTE CORPORATION (US) | 2014-01-09 | — | — | WO | disclosed |