Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.44 |
| ▸ | FASN | P49327 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15544532 | 0.88 | SIGMAR1 (0.44) | SIGMAR1OPRM1FASNKCNH2CHRM2 | |
| SCHEMBL15543949 | 0.88 | SIGMAR1 (0.47) | SIGMAR1OPRM1FASNKCNH2CHRM2 | |
| SCHEMBL15544411 | 0.85 | SIGMAR1 (0.52) | SIGMAR1OPRM1FASNKCNH2CHRM2 | |
| SCHEMBL15544705 | 0.82 | FASN (0.40) | SIGMAR1OPRM1FASNKCNH2SSTR5 | |
| SCHEMBL23015954 | 0.81 | SIGMAR1 (0.52) | SIGMAR1OPRM1FASNCHRM2CHRM3 | |
| SCHEMBL15544918 | 0.80 | SIGMAR1 (0.47) | SIGMAR1OPRM1FASNKCNH2CHRM2 | |
| SCHEMBL23015964 | 0.80 | SIGMAR1 (0.67) | SIGMAR1OPRM1FASNKCNH2CHRM2 | |
| SCHEMBL15543324 | 0.79 | FASN (0.40) | SIGMAR1OPRM1FASNKCNH2 | |
| SCHEMBL23015951 | 0.79 | FASN (0.53) | SIGMAR1OPRM1FASN | |
| SCHEMBL4536273 | 0.79 | FASN (0.57) | FASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |