Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | LTB4R | Q15722 | 5/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4846737 | 0.92 | HDAC1 (0.48) | POLBMEN1KMT2ALTB4RHDAC1 | |
| SCHEMBL1553849 | 0.79 | ALDH1A1 (0.50) | POLBMEN1KMT2ALTB4RHDAC1 | |
| SCHEMBL1554573 | 0.78 | NPSR1 (0.47) | POLBMEN1KMT2ALTB4RHDAC1 | |
| SCHEMBL7359038 | 0.77 | LTB4R (0.68) | POLBMEN1KMT2ALTB4RHDAC1 | |
| SCHEMBL7434110 | 0.76 | LTB4R (0.53) | POLBMEN1KMT2ALTB4RHDAC1 | |
| Hydrochloric Acid SCHEMBL1579945 | 0.74 | LTB4R (0.58) | POLBMEN1KMT2ALTB4RHDAC1 | |
| SCHEMBL1553818 | 0.74 | KMT2A (0.51) | POLBMEN1KMT2ALTB4RHDAC1 | |
| SCHEMBL1553934 | 0.74 | ALDH1A1 (0.57) | POLBMEN1KMT2ALTB4RHDAC1 | |
| SCHEMBL7433938 | 0.73 | PPARA (0.50) | POLBMEN1KMT2ALTB4RHDAC1 | |
| SCHEMBL13561126 | 0.73 | HDAC1 (0.79) | MEN1KMT2ALTB4RHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934307-B1 | SUBSTITUTED AZABICYLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF THE PRODUCTION OF TNF AND CYCLIC AMP PHOSPHODIESTERASE | AVENTIS PHARMA LTD (GB) | 2011-04-27 | — | — | EP | disclosed |
| EP-2223920-A2 | Substituted azabicyclic compounds | Aventis Pharma Limited (GB) | 2010-09-01 | — | — | EP | disclosed |